期刊
NEW JOURNAL OF CHEMISTRY
卷 45, 期 31, 页码 13692-13746出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/d1nj01696b
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In the past two decades, significant progress has been made in the research of transition-metal catalyzed C-H functionalization of indoles, particularly in terms of positional-selectivity and site-selectivity. Researchers have successfully achieved the functionalization of indole C-H bonds through strategies such as introducing Lewis-basic directing groups.
Over the last two decades, transition-metal catalyzed C-H functionalization of indoles has emerged as an area of extensive research and tremendous progress has been made in this regard. Early developments led to the positional-selective C-H functionalization at the C3 and C2-positions of indoles, based on the inherent reactivity of indoles and the application of Lewis-basic directing groups. Despite the challenges associated with lower accessibility of the C-H bonds on the benzenoid ring, considerable efforts have also been made in the development of elegant methodologies to enable site-selective C-H functionalization on the benzenoid moiety, at C4-C7 positions. This review summarises a wide range of useful transformations, including C-H arylation, alkenylation, alkynylation, acylation, nitration, borylation, annulations, and amidation with the aid of various transition-metal catalysts.
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