3.8 Article

The road to conception for women with multiple sclerosis

出版社

SAGE PUBLICATIONS INC
DOI: 10.1177/20552173211032313

关键词

Multiple sclerosis; pregnancy; conception; disease modifying therapies; family planning

资金

  1. Biogen MA Inc. [CAN-MSG-17-11120]

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This prospective real world study aims to gain insight into the various paths to conception that women with MS take, including the use of assisted reproductive technologies and decisions regarding disease modifying therapy. The study highlights the lack of international consensus on managing these women and the importance of providing real world data through studies like CANPREG-MS.
Objective The objective of this prospective real world study is to gain insight into the different roads to conception that women with MS take as part of the prospective Canadian Multiple Sclerosis Pregnancy Study (CANPREG-MS). Methods Participants are women with MS who are planning a pregnancy. Data cut-off for analyses was April 30, 2020. Results We believe this is the first prospective National study of women with MS planning pregnancies. The data are for the first 44 women enrolled of whom 26 achieved pregnancy by cut-off date. Seven women used assisted reproductive technologies (ARTs); 6 stopped disease modifying therapy (DMT) against their neurologists' recommendations; 6 had an interruption(s) in trying to conceive due to MS relapses, MRI-detected inflammation, or limited windows of opportunity between DMT courses. Conclusion The study illustrates the roads that women take to conception, even if they are on the same therapy and have similar clinical expression of MS. Advice given by treating neurologists on washout periods show discrepancies. This paper highlights the real problem that there is no definitive, international consensus on managing these women due to the lack of real world data and thus the goal of CANPREG-MS is to provide such real world data.

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