期刊
MEDICAL IMAGING 2020: DIGITAL PATHOLOGY
卷 11320, 期 -, 页码 -出版社
SPIE-INT SOC OPTICAL ENGINEERING
DOI: 10.1117/12.2549994
关键词
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资金
- U.S. National Institutes of Health (NIH) [R01CA156775, R01CA204254, R01HL140325, R21CA231911]
- Cancer Prevention and Research Institute of Texas (CPRIT) grant [RP190588]
- Canary Islands Government through the ACIISI (Canarian Agency for Research, Innovation and the Information Society), ITHACA project [2017010164]
- Agencia Canaria de Investigacion, Innovacion y Sociedad de la Informacion (ACIISI) of the Conserjeria de Economia, Industria, Comercio y Conocimiento of the Gobierno de Canarias - European Social Fund (FSE)
A method utilizing a generative adversarial network to synthesize hyperspectral imaging from standard RGB images of breast cancer tissue has been proposed in this study. The synthesized hyperspectral images achieved high structural similarity and low mean absolute error compared to actual hyperspectral images. Further research is needed to validate the effectiveness of this method on larger datasets.
Hyperspectral imaging (HSI), which acquires up to hundreds of bands, has been proposed as a promising imaging modality for digitized histology beyond RGB imaging to provide more quantitative information to assist pathologists with disease detection in samples. While digitized RGB histology is quite standardized and easy to acquire, histological HSI often requires custom-made equipment and longer imaging times compared to RGB. In this work, we present a dataset of corresponding RGB digitized histology and histological HSI of breast cancer, and we develop a conditional generative adversarial network (GAN) to artificially synthesize HSI from standard RGB images of normal and cancer cells. The results of the GAN synthesized HSI are promising, showing structural similarity (SSIM) of approximately 80% and mean absolute error (MAE) of 6 to 11%. Further work is needed to establish the ability of generating HSI from RGB images on larger datasets.
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