4.6 Review

Metabolic Reprogramming in Anticancer Drug Resistance: A Focus on Amino Acids

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Review Oncology

Cysteine metabolic circuitries: druggable targets in cancer

Vasco D. B. Bonifacio et al.

Summary: Cysteine plays a crucial role in cancer metabolic remodeling by contributing to redox control, cellular bioenergetics stimulation, and epigenetic regulation. Understanding the importance of cysteine in cancer biology, its potential as prognostic cancer markers, and targeting cysteine metabolism for cancer treatment will be discussed in this review.

BRITISH JOURNAL OF CANCER (2021)

Article Biochemistry & Molecular Biology

In Vivo Evidence for Serine Biosynthesis-Defined Sensitivity of Lung Metastasis, but Not of Primary Breast Tumors, to mTORC1 Inhibition

Gianmarco Rinaldi et al.

Summary: This study found that there are different metabolic and nutrient requirements to activate growth signaling between lung metastatic niche and primary breast cancer site. Breast cancer-derived lung metastases use the serine biosynthesis pathway to fuel mTORC1 growth signaling, while primary breast tumors do not rely on this pathway.

MOLECULAR CELL (2021)

Review Oncology

Fat and Furious: Lipid Metabolism in Antitumoral Therapy Response and Resistance

Marina Bacci et al.

Summary: Lipid metabolic reprogramming plays a significant role in influencing the response to antitumoral therapies and sustaining resistance. Aberrant lipid metabolism has emerged as a potential vulnerability in therapy-resistant cancers.

TRENDS IN CANCER (2021)

Review Endocrinology & Metabolism

Targeting extracellular nutrient dependencies of cancer cells

Javier Garcia-Bermudez et al.

MOLECULAR METABOLISM (2020)

Article Biochemistry & Molecular Biology

Co-Expression Effect of SLC7A5/SLC3A2 to Predict Response to Endocrine Therapy in Oestrogen-Receptor-Positive Breast Cancer

Lutfi H. Alfarsi et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Review Biochemistry & Molecular Biology

Stable Isotopes for Tracing Mammalian-Cell Metabolism In Vivo

Juan Fernandez-Garcia et al.

TRENDS IN BIOCHEMICAL SCIENCES (2020)

Article Multidisciplinary Sciences

Cysteine depletion induces pancreatic tumor ferroptosis in mice

Michael A. Badgley et al.

SCIENCE (2020)

Review Multidisciplinary Sciences

Dietary modifications for enhanced cancer therapy

Naama Kanarek et al.

NATURE (2020)

Article Cell Biology

Extracellular serine controls epidermal stem cell fate and tumour initiation

Sanjeethan C. Baksh et al.

NATURE CELL BIOLOGY (2020)

Article Cell Biology

Induction of a Timed Metabolic Collapse to Overcome Cancer Chemoresistance

Nick van Gastel et al.

CELL METABOLISM (2020)

Article Medicine, Research & Experimental

Targeting glutamine metabolism enhances tumor-specific immunity by modulating suppressive myeloid cells

Min-Hee Oh et al.

JOURNAL OF CLINICAL INVESTIGATION (2020)

Article Multidisciplinary Sciences

Serine restriction alters sphingolipid diversity to constrain tumour growth

Thangaselvam Muthusamy et al.

NATURE (2020)

Article Multidisciplinary Sciences

Purine metabolism regulates DNA repair and therapy resistance in glioblastoma

Weihua Zhou et al.

NATURE COMMUNICATIONS (2020)

Review Biochemistry & Molecular Biology

Amino Acids and Their Transporters in T Cell Immunity and Cancer Therapy

Weimin Wang et al.

MOLECULAR CELL (2020)

Article Multidisciplinary Sciences

Cancer SLC43A2 alters T cell methionine metabolism and histone methylation

Yingjie Bian et al.

NATURE (2020)

Review Cell Biology

Oncology Therapeutics Targeting the Metabolism of Amino Acids

Nefertiti Muhammad et al.

Review Cell Biology

Cancer cell metabolic reprogramming: a keystone for the response to immunotherapy

Michael Cerezo et al.

CELL DEATH & DISEASE (2020)

Article Biochemistry & Molecular Biology

Neurons Release Serine to Support mRNA Translation in Pancreatic Cancer

Robert S. Banh et al.

Article Oncology

S-adenosylmethionine biosynthesis is a targetable metabolic vulnerability of cancer stem cells

Elena Strekalova et al.

BREAST CANCER RESEARCH AND TREATMENT (2019)

Review Cell Biology

Cancer Metabolism Drives a Stromal Regenerative Response

Simon Schworer et al.

CELL METABOLISM (2019)

Article Cell Biology

Macrophage-Released Pyrimidines Inhibit Gemcitabine Therapy in Pancreatic Cancer

Christopher J. Halbrook et al.

CELL METABOLISM (2019)

Article Multidisciplinary Sciences

Breast cancer cells rely on environmental pyruvate to shape the metastatic niche

Ilaria Elia et al.

NATURE (2019)

Review Biotechnology & Applied Microbiology

Tryptophan metabolism as a common therapeutic target in cancer, neurodegeneration and beyond

Michael Platten et al.

NATURE REVIEWS DRUG DISCOVERY (2019)

Article Multidisciplinary Sciences

CD8+ T cells regulate tumour ferroptosis during cancer immunotherapy

Weimin Wang et al.

NATURE (2019)

Article Multidisciplinary Sciences

LLGL2 rescues nutrient stress by promoting leucine uptake in ER+ breast cancer

Yasuhiro Saito et al.

NATURE (2019)

Article Biochemistry & Molecular Biology

Methionine is a metabolic dependency of tumor-initiating cells

Zhenxun Wang et al.

NATURE MEDICINE (2019)

Article Multidisciplinary Sciences

Cystine-glutamate antiporter xCT deficiency suppresses tumor growth while preserving antitumor immunity

Michael D. Arensman et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)

Article Multidisciplinary Sciences

Hypoxia-induced switch in SNAT2/SLC38A2 regulation generates endocrine resistance in breast cancer

Matteo Morotti et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)

Review Cell Biology

Mechanisms and Implications of Metabolic Heterogeneity in Cancer

Jiyeon Kim et al.

CELL METABOLISM (2019)

Article Biochemistry & Molecular Biology

SLC1A3 contributes to L-asparaginase resistance in solid tumors

Jianhui Sun et al.

EMBO JOURNAL (2019)

Article Multidisciplinary Sciences

Glutamine blockade induces divergent metabolic programs to overcome tumor immune evasion

Robert D. Leone et al.

SCIENCE (2019)

Article Multidisciplinary Sciences

Metabolic landscape of the tumor microenvironment at single cell resolution

Zhengtao Xiao et al.

NATURE COMMUNICATIONS (2019)

Article Multidisciplinary Sciences

Metabolomic adaptations and correlates of survival to immune checkpoint blockade

Haoxin Li et al.

NATURE COMMUNICATIONS (2019)

Review Nutrition & Dietetics

Targeting Glutathione Metabolism: Partner in Crime in Anticancer Therapy

Enrico Desideri et al.

NUTRIENTS (2019)

Article Oncology

Targeting the arginine metabolic brake enhances immunotherapy for leukaemia

Francis Mussai et al.

INTERNATIONAL JOURNAL OF CANCER (2019)

Article Multidisciplinary Sciences

Spatially resolved metabolomics to discover tumor-associated metabolic alterations

Chenglong Sun et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)

Review Oncology

Platinum Resistance in Ovarian Cancer: Role of DNA Repair

Giovanna Damia et al.

CANCERS (2019)

Review Oncology

Methionine metabolism in health and cancer: a nexus of diet and precision medicine

Sydney M. Sanderson et al.

NATURE REVIEWS CANCER (2019)

Article Biochemistry & Molecular Biology

Glutathione reductase mediates drug resistance in glioblastoma cells by regulating redox homeostasis

Zhongling Zhu et al.

JOURNAL OF NEUROCHEMISTRY (2018)

Review Medicine, Research & Experimental

Metabolic interactions in cancer: cellular metabolism at the interface between the microenvironment, the cancer cell phenotype and the epigenetic landscape

Gianmarco Rinaldi et al.

WILEY INTERDISCIPLINARY REVIEWS-SYSTEMS BIOLOGY AND MEDICINE (2018)

Review Biochemistry & Molecular Biology

Redox Paradox: A Novel Approach to Therapeutics-Resistant Cancer

Luksana Chaiswing et al.

ANTIOXIDANTS & REDOX SIGNALING (2018)

Article Pharmacology & Pharmacy

Exploiting methionine restriction for cancer treatment

Sushma Chaturvedi et al.

BIOCHEMICAL PHARMACOLOGY (2018)

Review Biochemistry & Molecular Biology

Targeting Glutamine Metabolism for Cancer Treatment

Yeon-Kyung Choi et al.

BIOMOLECULES & THERAPEUTICS (2018)

Review Endocrinology & Metabolism

Branched-chain amino acid metabolism in cancer

Elitsa A. Ananieva et al.

CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE (2018)

Article Biochemistry & Molecular Biology

Metabolic vulnerability of cisplatin-resistant cancers

Florine Obrist et al.

EMBO JOURNAL (2018)

Review Cell Biology

Glutathione metabolism in cancer progression and treatment resistance

Ankita Bansal et al.

JOURNAL OF CELL BIOLOGY (2018)

Article Multidisciplinary Sciences

Asparagine bioavailability governs metastasis in a model of breast cancer

Simon R. V. Knott et al.

NATURE (2018)

Review Cell Biology

Metabolic Hallmarks of Metastasis Formation

Ilaria Elia et al.

TRENDS IN CELL BIOLOGY (2018)

Article Multidisciplinary Sciences

Spatial maps of prostate cancer transcriptomes reveal an unexplored landscape of heterogeneity

Emelie Berglund et al.

NATURE COMMUNICATIONS (2018)

Review Cell & Tissue Engineering

Cancer Stem Cells (CSCs) in Drug Resistance and their Therapeutic Implications in Cancer Treatment

Lan Thi Hanh Phi et al.

STEM CELLS INTERNATIONAL (2018)

Article Medicine, Research & Experimental

Can IDO activity predict primary resistance to anti-PD-1 treatment in NSCLC?

Andrea Botticelli et al.

JOURNAL OF TRANSLATIONAL MEDICINE (2018)

Article Multidisciplinary Sciences

Histidine catabolism is a major determinant of methotrexate sensitivity

Naama Kanarek et al.

NATURE (2018)

Article Biochemistry & Molecular Biology

CD44v-dependent upregulation of xCT is involved in the acquisition of cisplatin-resistance in human lung cancer A549 cells

Sayo Horibe et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2018)

Article Multidisciplinary Sciences

Autophagy maintains tumour growth through circulating arginine

Laura Poillet-Perez et al.

NATURE (2018)

Review Oncology

The Influence of Metabolism on Drug Response in Cancer

Esther A. Zaal et al.

FRONTIERS IN ONCOLOGY (2018)

Review Oncology

The Genetic/Non-genetic Duality of Drug 'Resistance' in Cancer

Ravi Salgia et al.

TRENDS IN CANCER (2018)

Article Biochemistry & Molecular Biology

Regulation of stem-like cancer cells by glutamine through β-catenin pathway mediated by redox signaling

Jianwei Liao et al.

MOLECULAR CANCER (2017)

Article Oncology

PPARδ Reprograms Glutamine Metabolism in Sorafenib-Resistant HCC

Mi-Jin Kim et al.

MOLECULAR CANCER RESEARCH (2017)

Article Multidisciplinary Sciences

Modulating the therapeutic response of tumours to dietary serine and glycine starvation

Oliver D. K. Maddocks et al.

NATURE (2017)

Article Multidisciplinary Sciences

Metabolic origins of spatial organization in the tumor microenvironment

Carlos Carmona-Fontaine et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)

Article Cell & Tissue Engineering

SLC7A11 Overexpression in Glioblastoma Is Associated with Increased Cancer Stem Cell-Like Properties

Monika D. Polewski et al.

STEM CELLS AND DEVELOPMENT (2017)

Review Cell Biology

Metabolic Interactions in the Tumor Microenvironment

Costas A. Lyssiotis et al.

TRENDS IN CELL BIOLOGY (2017)

Review Immunology

Metabolic Hallmarks of Tumor and immune Cells in the Tumor Microenvironment

Kathrin Renner et al.

FRONTIERS IN IMMUNOLOGY (2017)

Article Oncology

Inhibition of arginase by CB-1158 blocks myeloid cell-mediated immune suppression in the tumor microenvironment

Susanne M. Steggerda et al.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2017)

Review Biochemistry & Molecular Biology

Targeting Metabolism for Cancer Therapy

Alba Luengo et al.

CELL CHEMICAL BIOLOGY (2017)

Review Biochemistry & Molecular Biology

Linking metabolic reprogramming to therapy resistance in cancer

Andrea Morandi et al.

BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER (2017)

Article Biochemistry & Molecular Biology

Cancer metabolism in space and time: Beyond the Warburg effect

Pierre Danhier et al.

BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS (2017)

Review Pharmacology & Pharmacy

Targeting amino acid metabolism for cancer therapy

Michael J. Lukey et al.

DRUG DISCOVERY TODAY (2017)

Article Immunology

Amino acid auxotrophy as a system of immunological control nodes

Peter J. Murray

NATURE IMMUNOLOGY (2016)

Review Oncology

Hallmarks of cancer stem cell metabolism

Patricia Sancho et al.

BRITISH JOURNAL OF CANCER (2016)

Article Biochemistry & Molecular Biology

Effector T Cells Abrogate Stroma-Mediated Chemoresistance in Ovarian Cancer

Weimin Wang et al.

Article Biochemistry & Molecular Biology

L-Arginine Modulates T Cell Metabolism and Enhances Survival and Anti-tumor Activity

Roger Geiger et al.

Article Biochemistry & Molecular Biology

Metabolic Heterogeneity in Human Lung Tumors

Christopher T. Hensley et al.

Article Multidisciplinary Sciences

Asparagine promotes cancer cell proliferation through use as an amino acid exchange factor

Abigail S. Krall et al.

NATURE COMMUNICATIONS (2016)

Review Oncology

Serine and one-carbon metabolism in cancer

Ming Yang et al.

NATURE REVIEWS CANCER (2016)

Review Oncology

Nutrient Exploitation within the Tumor-Stroma Metabolic Crosstalk

Andrea Morandi et al.

TRENDS IN CANCER (2016)

Review Oncology

From Krebs to clinic: glutamine metabolism to cancer therapy

Brian J. Altman et al.

NATURE REVIEWS CANCER (2016)

Article Multidisciplinary Sciences

Diversion of aspartate in ASS1-deficient tumours fosters de novo pyrimidine synthesis

Shiran Rabinovich et al.

NATURE (2015)

Article Multidisciplinary Sciences

Tryptophan derivatives regulate the transcription of Oct4 in stem-like cancer cells

Jie Cheng et al.

NATURE COMMUNICATIONS (2015)

Review Biotechnology & Applied Microbiology

Development of recombinant methioninase to target the general cancer-specific metabolic defect of methionine dependence: a 40-year odyssey

Robert M. Hoffman

EXPERT OPINION ON BIOLOGICAL THERAPY (2015)

Review Oncology

Tumorigenesis: it takes a village

Doris P. Tabassum et al.

NATURE REVIEWS CANCER (2015)

Article Biotechnology & Applied Microbiology

Heterogeneity of tumor-induced gene expression changes in the human metabolic network

Jie Hu et al.

NATURE BIOTECHNOLOGY (2013)

Article Multidisciplinary Sciences

Pyruvate carboxylase is required for glutamine-independent growth of tumor cells

Tzuling Cheng et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)

Review Biochemistry & Molecular Biology

Regulation of glutathione synthesis

Shelly C. Lu

MOLECULAR ASPECTS OF MEDICINE (2009)