4.5 Review

Targeting cancer with antibody-drug conjugates: Promises and challenges

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Review Biotechnology & Applied Microbiology

Antibody-drug conjugates (ADCs) delivering pyrrolobenzodiazepine (PBD) dimers for cancer therapy

John A. Hartley

Summary: Reviewing the clinical efficacy and safety data from almost forty clinical trials of PBD dimer-containing ADCs highlights the complexities and challenges of ADC early clinical development. It enables some conclusions to be made about reasons for failure and suggests strategies to optimize the future clinical development of this promising class of ADCs in a rapidly expanding field.

EXPERT OPINION ON BIOLOGICAL THERAPY (2021)

Review Oncology

Hepatic veno-occlusive disease in allogeneic stem cell transplant recipients with prior exposure to gemtuzumab ozogamicin or inotuzumab ozogamicin

Abdullah Ladha et al.

Summary: Veno-occlusive disease (VOD) is a common and serious complication in SCT recipients, and novel agents such as GO and InO for treating AML and ALL may increase the risk of VOD in these patients.

LEUKEMIA & LYMPHOMA (2021)

Article Oncology

HDP-101, an Anti-BCMA Antibody-Drug Conjugate, Safely Delivers Amanitin to Induce Cell Death in Proliferating and Resting Multiple Myeloma Cells

Vianihuini Figueroa-Vazquez et al.

Summary: HDP-101, an anti-BCMA antibody conjugated with an amanitin derivative, demonstrates high efficacy against multiple myeloma cells while sparing BCMA-negative cells. It induces tumor regression in animal models at low doses and shows good tolerability, suggesting a promising therapeutic approach to overcome drug resistance in this disease.

MOLECULAR CANCER THERAPEUTICS (2021)

Article Oncology

A Randomized Phase II Study of AGS-16C3F Versus Axitinib in Previously Treated Patients with Metastatic Renal Cell Carcinoma

Christian Kollmannsberger et al.

Summary: The phase II study of AGS-16C3F versus axitinib in metastatic renal cell carcinoma did not show a significant improvement in progression-free survival with AGS-16C3F. However, there were no significant differences in overall survival between the two treatment arms. Axitinib had a higher incidence of diarrhea, while AGS-16C3F had more frequent ocular toxicities.

ONCOLOGIST (2021)

Article Oncology

Efficacy and Safety of Rovalpituzumab Tesirine Compared With Topotecan as Second-Line Therapy in DLL3-High SCLC: Results From the Phase 3 TAHOE Study

Fiona Blackhall et al.

Summary: The study compared Rova-T and topotecan as second-line therapy in patients with SCLC expressing high levels of DLL3, showing inferior overall survival and higher rates of adverse reactions with Rova-T. This highlights the ongoing unmet therapeutic need in this population.

JOURNAL OF THORACIC ONCOLOGY (2021)

Article Oncology

Safety, tolerability, and pharmacokinetics of BAT8001 in patients with HER2-positive breast cancer: An open-label, dose-escalation, phase I study

Ruoxi Hong et al.

Summary: The study evaluated the safety, tolerability, pharmacokinetics, and anti-tumor activity of the novel drug BAT8001 targeting HER2-positive breast cancer patients. BAT8001 demonstrated promising anti-tumor activity and has the potential to provide a new therapeutic option for patients with metastatic HER2-positive breast cancer.

CANCER COMMUNICATIONS (2021)

Article Oncology

Dolaflexin: A Novel Antibody-Drug Conjugate Platform Featuring High Drug Loading and a Controlled Bystander Effect

Aleksandr Yurkovetskiy et al.

Summary: After years of effort, ADCs have gained momentum as a therapeutic modality, with dolaflexin being a novel ADC technology that overcomes key limitations of common ADC platforms. Preclinical studies have shown that the HER2-targeted dolaflexin ADC has a lower threshold for cell killing in tumors with low HER2 expression and induces tumor regressions in xenograft models resistant to T-DM1, highlighting its potential as a promising therapeutic option.

MOLECULAR CANCER THERAPEUTICS (2021)

Review Chemistry, Multidisciplinary

Site-selective modification strategies in antibody-drug conjugates

Stephen J. Walsh et al.

Summary: ADCs utilize antibodies' targeting ability to deliver cytotoxic payloads to specific cells. Research focuses on the critical nature of the linkage strategy and generation of homogeneous constructs for precise drug loading. Homogeneous ADCs have superior pharmacological profiles compared to heterogeneous counterparts.

CHEMICAL SOCIETY REVIEWS (2021)

Article Oncology

Open-label, Multicenter, Phase II Study of RC48-ADC, a HER2-Targeting Antibody-Drug Conjugate, in Patients with Locally Advanced or Metastatic Urothelial Carcinoma

Xinan Sheng et al.

Summary: RC48-ADC shows promising efficacy in patients with HER2(+) locally advanced or metastatic urothelial carcinoma, significantly reducing disease progression risk, with manageable safety profile.

CLINICAL CANCER RESEARCH (2021)

Review Cell Biology

Potential drugs used in the antibody-drug conjugate (ADC) architecture for cancer therapy

Sajad Yaghoubi et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2020)

Review Biotechnology & Applied Microbiology

Antibody prodrugs for cancer

W. Michael Kavanaugh

EXPERT OPINION ON BIOLOGICAL THERAPY (2020)

Editorial Material Chemistry, Medicinal

Targeting anti-apoptotic BCL-2 family proteins for cancer treatment

Xuan Zhang et al.

FUTURE MEDICINAL CHEMISTRY (2020)

Article Pharmacology & Pharmacy

Reducing the antigen-independent toxicity of antibody-drug conjugates by minimizing their non-specific clearance through PEGylation

Jessica K. Simmons et al.

TOXICOLOGY AND APPLIED PHARMACOLOGY (2020)

Review Pharmacology & Pharmacy

Recent advances of antibody drug conjugates for clinical applications

Pengxuan Zhao et al.

ACTA PHARMACEUTICA SINICA B (2020)

Article Pharmacology & Pharmacy

Use of translational modeling and simulation for quantitative comparison of PF-06804103, a new generation HER2 ADC, with Trastuzumab-DM1

Alison Betts et al.

JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS (2020)

Meeting Abstract Oncology

SGN-B6A: A new MMAE ADC targeting integrin beta-6 in multiple carcinoma indications

Robert P. Lyon et al.

CANCER RESEARCH (2020)

Article Biochemical Research Methods

Improved Inhibition of Tumor Growth by Diabody-Drug Conjugates via Half-Life Extension

Qing Li et al.

BIOCONJUGATE CHEMISTRY (2019)

Review Biochemical Research Methods

Cutting-edge multi-level analytical and structural characterization of antibody-drug conjugates: present and future

Alain Beck et al.

EXPERT REVIEW OF PROTEOMICS (2019)

Review Biochemistry & Molecular Biology

HER2 Directed Antibody-Drug-Conjugates beyond T-DM1 in Breast Cancer

Gabriel Rinnerthaler et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

Review Pharmacology & Pharmacy

The Analysis of Key Factors Related to ADCs Structural Design

Haichao Tang et al.

FRONTIERS IN PHARMACOLOGY (2019)

Review Chemistry, Medicinal

The Utility of Highly Toxic Marine-Sourced Compounds

David J. Newman

MARINE DRUGS (2019)

Article Pharmacology & Pharmacy

Effect of Size on Solid Tumor Disposition of Protein Therapeutics

Zhe Li et al.

DRUG METABOLISM AND DISPOSITION (2019)

Article Medicine, Legal

An FDA oncology analysis of toxicities associated with PBD-containing antibody-drug conjugates

Haleh Saber et al.

REGULATORY TOXICOLOGY AND PHARMACOLOGY (2019)

Article Chemistry, Multidisciplinary

Secreted Gal-3BP is a novel promising target for non-internalizing Antibody-Drug Conjugates

Francesco Giansanti et al.

JOURNAL OF CONTROLLED RELEASE (2019)

Article Oncology

APOMAB Antibody-Drug Conjugates Targeting Dead Tumor Cells are Effective In Vivo

Alexander H. Staudacher et al.

MOLECULAR CANCER THERAPEUTICS (2019)

Article Chemistry, Medicinal

Site-specific and hydrophilic ADCs through disulfide-bridged linker and branched PEG

Shuai Shao et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2018)

Review Oncology

Resistance to Antibody-Drug Conjugates

Sara Garcia-Alonso et al.

CANCER RESEARCH (2018)

Article Pharmacology & Pharmacy

Gemtuzumab ozogamicin for the treatment of acute myeloid leukemia

Jeffrey Baron et al.

EXPERT REVIEW OF CLINICAL PHARMACOLOGY (2018)

Article Medicine, Research & Experimental

T-DM1-resistant cells gain high invasive activity via EGFR and integrin cooperated pathways

Yukinori Endo et al.

Review Chemistry, Multidisciplinary

From Anthramycin to Pyrrolobenzodiazepine (PBD)-Containing Antibody-Drug Conjugates (ADCs)

Julia Mantaj et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2017)

Article Biochemical Research Methods

Charge variants characterization of a monoclonal antibody by ion exchange chromatography coupled on-line to native mass spectrometry: Case study after a long-term storage at+5 °C

Y. Leblanc et al.

JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES (2017)

Article Chemistry, Multidisciplinary

A non-internalizing antibody-drug conjugate based on an anthracycline payload displays potent therapeutic activity in vivo

Alberto Dal Corso et al.

JOURNAL OF CONTROLLED RELEASE (2017)

Review Biotechnology & Applied Microbiology

Strategies and challenges for the next generation of antibody drug conjugates

Alain Beck et al.

NATURE REVIEWS DRUG DISCOVERY (2017)

Review Chemistry, Medicinal

The Chemical Design and Synthesis of Linkers Used in Antibody Drug Conjugates

Mark Frigerio et al.

CURRENT TOPICS IN MEDICINAL CHEMISTRY (2017)

Article Biochemical Research Methods

Imaged capillary isoelectric focusing in native condition: A novel and successful example

Xin Zhang et al.

ANALYTICAL BIOCHEMISTRY (2017)

Article Biochemical Research Methods

Investigation of Hydrophilic Auristatin Derivatives for Use in Antibody Drug Conjugates

Brian A. Mendelsohn et al.

BIOCONJUGATE CHEMISTRY (2017)

Article Chemistry, Analytical

Structural Characterization of a Monoclonal Antibody-Maytansinoid Immunoconjugate

Quanzhou Luo et al.

ANALYTICAL CHEMISTRY (2016)

Review Biochemistry & Molecular Biology

Linkers Having a Crucial Role in Antibody-Drug Conjugates

Jun Lu et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2016)

Article Medicine, Research & Experimental

Antibody-drug conjugate targeting CD46 eliminates multiple myeloma cells

Daniel W. Sherbenou et al.

JOURNAL OF CLINICAL INVESTIGATION (2016)

Review Chemistry, Medicinal

Physical and Chemical Stability of Antibody Drug Conjugates: Current Status

Philip L. Ross et al.

JOURNAL OF PHARMACEUTICAL SCIENCES (2016)

Review Oncology

Mechanisms of Resistance to Antibody-Drug Conjugates

Frank Loganzo et al.

MOLECULAR CANCER THERAPEUTICS (2016)

Article Chemistry, Medicinal

Straightforward Glycoengineering Approach to Site-Specific Antibody-Pyrrolobenzodiazepine Conjugates

Pamela Thompson et al.

ACS MEDICINAL CHEMISTRY LETTERS (2016)

Review Immunology

Posttranslational Modifications and the Immunogenicity of Biotherapeutics

Roy Jefferis

JOURNAL OF IMMUNOLOGY RESEARCH (2016)

Review Pharmacology & Pharmacy

Antibody Drug Conjugates: Design and Selection of Linker, Payload and Conjugation Chemistry

Jessica R. McCombs et al.

AAPS JOURNAL (2015)

Review Biotechnology & Applied Microbiology

Current methods for the synthesis of homogeneous antibody-drug conjugates

Alicja M. Sochaj et al.

BIOTECHNOLOGY ADVANCES (2015)

Article Oncology

A novel humanized anti-HER2 antibody conjugated with MMAE exerts potent anti-tumor activity

Xuejing Yao et al.

BREAST CANCER RESEARCH AND TREATMENT (2015)

Review Pharmacology & Pharmacy

Antibody-targeted drugs and drug resistance-Challenges and solutions

LeeRon Shefet-Carasso et al.

DRUG RESISTANCE UPDATES (2015)

Review Ophthalmology

Ocular Adverse Events Associated with Antibody-Drug Conjugates in Human Clinical Trials

Joshua Seth Eaton et al.

JOURNAL OF OCULAR PHARMACOLOGY AND THERAPEUTICS (2015)

Review Chemistry, Multidisciplinary

Evolving Strategies for Target Selection for Antibody-Drug Conjugates

Marc Damelin et al.

PHARMACEUTICAL RESEARCH (2015)

Review Chemistry, Multidisciplinary

Current ADC Linker Chemistry

Nareshkumar Jain et al.

PHARMACEUTICAL RESEARCH (2015)

Article Biochemical Research Methods

Bridging Disulfides for Stable and Defined Antibody Drug Conjugates

George Badescu et al.

BIOCONJUGATE CHEMISTRY (2014)

Article Biochemical Research Methods

Auristatin Antibody Drug Conjugate Physical Instability and the Role of Drug Payload

Yilma T. Adem et al.

BIOCONJUGATE CHEMISTRY (2014)

Review Oncology

Trastuzumab emtansine: mechanisms of action and drug resistance

Mark Barok et al.

BREAST CANCER RESEARCH (2014)

Review Pharmacology & Pharmacy

Antibody-drug conjugates: current status and future directions

Heidi L. Perez et al.

DRUG DISCOVERY TODAY (2014)

Review Medicine, Research & Experimental

Antibody-Drug Conjugates in Cancer Therapy

Eric L. Sievers et al.

ANNUAL REVIEW OF MEDICINE, VOL 64 (2013)

Article Biochemical Research Methods

Total Antibody Quantification for MMAE-Conjugated Antibody-Drug Conjugates: Impact of Assay Format and Reagents

Katherine R. Kozak et al.

BIOCONJUGATE CHEMISTRY (2013)

Article Biochemical Research Methods

Investigation into Temperature-Induced Aggregation of an Antibody Drug Conjugate

Nia S. Beckley et al.

BIOCONJUGATE CHEMISTRY (2013)

Article Biotechnology & Applied Microbiology

The use of an antibody drug conjugate, glembatumumab vedotin (CDX-011), for the treatment of breast cancer

Christopher H. Keir et al.

EXPERT OPINION ON BIOLOGICAL THERAPY (2012)

Article Biochemical Research Methods

Site-specific chemical protein conjugation using genetically encoded aldehyde tags

David Rabuka et al.

NATURE PROTOCOLS (2012)

Article Multidisciplinary Sciences

Synthesis of site-specific antibody-drug conjugates using unnatural amino acids

Jun Y. Axup et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)

Article Oncology

Antibody Conjugate Therapeutics: Challenges and Potential

Beverly A. Teicher et al.

CLINICAL CANCER RESEARCH (2011)

Review Medicine, Research & Experimental

Analytical methods for physicochemical characterization of antibody drug conjugates

Aditya Wakankar et al.

Article Biotechnology & Applied Microbiology

Advances in the assessment and control of the effector functions of therapeutic antibodies

Xu-Rong Jiang et al.

NATURE REVIEWS DRUG DISCOVERY (2011)

Article Biochemical Research Methods

Post-translational Modifications Differentially Affect IgG1 Conformation and Receptor Binding

Damian Houde et al.

MOLECULAR & CELLULAR PROTEOMICS (2010)

Review Multidisciplinary Sciences

Cell adhesion molecules nectins and associating proteins: Implications for physiology and pathology

Hisakazu Ogita et al.

PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES (2010)

Article Biotechnology & Applied Microbiology

Site-specific conjugation of a cytotoxic drug to an antibody improves the therapeutic index

Jagath R. Junutula et al.

NATURE BIOTECHNOLOGY (2008)