期刊
ASIAN PACIFIC JOURNAL OF TROPICAL BIOMEDICINE
卷 11, 期 8, 页码 327-334出版社
WOLTERS KLUWER MEDKNOW PUBLICATIONS
DOI: 10.4103/2221-1691.319567
关键词
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Flavonoids like kaempferol and quercetin exhibit antiviral, antioxidant, anti-inflammatory, and immunomodulatory effects against SARS-CoV-2, which may have beneficial effects in controlling or treating COVID-19.
Severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) is a novel coronavirus identified at the end of 2019. It is recognized as the causative agent of coronavirus disease 2019 (COVID-19). Flavonoids have been shown to exhibit therapeutical effect on complications related to COVID-19. The present study reviews possible therapeutic benefits of flavonoids on SARS-CoV-2. The Web of Science, PubMed, Scopus, and Google Scholar were searched using keywords: COVID-19, SARS-CoV-2, Kaempferol and Quercetin in the Title/Abstract. Relevant published articles in the English language until August 2020 were considered. Kaempferol and quercetin showed antiviral properties such as inhibition of protein kinase B and phosphorylation of protein kinase and blocking effects on a selective channel (3a channel) expressed in SARS-CoV infected cells. They also reduced the level of reactive oxygen species, expression of inducible nitric oxide synthase, pro-inflammatory mediators including TNF-alpha, IL-1 alpha, IL-1 beta, IL-6, IL-10, and IL-12 p70, and chemokines. Kaempferol and quercetin might exert beneficial effects in the control or treatment of COVID-19 because of their antiviral, antioxidant, anti-inflammatory, and immunomodulatory effects.
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