期刊
GREEN SYNTHESIS AND CATALYSIS
卷 2, 期 3, 页码 295-298出版社
KEAI PUBLISHING LTD
DOI: 10.1016/j.gresc.2021.05.002
关键词
N -Heterocyclic carbene; Organocatalysis; Chiral oxidant; Asymmetric; 3-hydroxylation; Radical reaction
资金
- National Natural Science Foundation of China
- 10 Talent Plan (Shicengci) of Guizhou Province
- Guizhou Province Returned Oversea Student Science and Technology Activity Program
- Science and Technology Department of Guizhou Province [21772029, 21801051, 21961006]
- Program of Introducing Talents of Discipline to Universities of China (111 Program) at Guizhou University [[2016]5649]
- Frontiers Science Center for Asymmetric Synthesis and Medicinal Molecules, Department of Education, Guizhou Province [(2014)-2]
- Guizhou Province First-Class Disciplines Project [[2018]2802, [2019]1020, Qiankehejichu-ZK[2021]Key033]
- Guizhou University of Traditional Chinese Medicine [D20023]
- Guizhou University (China) [(2020)004]
- Singapore National Research Foundation under its NRF Investigatorship [GNYL(2017)008]
- Ministry of Education, Singapore, under its MOE AcRF Tier 1 Award
- MOE AcRF Tier 3 Award
- Agency for Science, Technology and Research (A*STAR) under its A*STAR AME IRG Award [NRF-NRFI2016-06]
- GSK-EDB Trust Fund [RG108/16, RG5/19, RG1/18]
- Nanyang Research Award Grant [MOE2018-T3-1-003]
- Nanyang Technological University [A1783c0008, A1783c0010]
A novel type of chiral oxidants has been developed for efficient and enantioselective /3-hydroxylation reaction of enals, using a commercially accessible and inexpensive NHC catalyst. Various /3-hydroxyl esters with different substituents and substitution patterns are obtained in moderate to excellent yields and enantioselectivities as the final products.
A novel type of chiral oxidants are developed for efficient and enantioselective /3-hydroxylation reaction of enals. The chiral oxidants can be easily obtained from readily available and inexpensive substituted benzoic acids and chiral prolinols. A commercially accessible and inexpensive achiral NHC catalyst is used for this catalytic approach. /3-Hydroxyl esters bearing various substituents and substitution patterns are afforded as the final products in moderate to excellent yields and enantioselectivities.
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