期刊
NEW JOURNAL OF CHEMISTRY
卷 45, 期 31, 页码 13747-13750出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/d0nj05886f
关键词
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A novel catalytic system has been developed for the direct enantioselective vinylogous aldol reaction between 3-alkylidene-2-oxindoles and pyrazole-4,5-diones. The bifunctional quinine-derived benzamide catalyst achieved highly functional rich pyrazolone moieties with excellent E/Z selectivity (>19:1) and high yields, as well as moderate enantioselectivity through H-bonding dual activation mode.
Here, a bifunctional quinine-derived benzamide catalyzed direct enantioselective vinylogous aldol reaction between 3-alkylidene-2-oxindoles and pyrazole-4,5-diones has been developed. This challenging protocol has been achieved via the H-bonding dual activation mode of the catalyst. Highly functional rich pyrazolone moieties having an oxindole core have been obtained with an excellent E/Z (>19 : 1), and high yields along with moderate enantioselectivity.
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