期刊
GREEN CHEMISTRY
卷 23, 期 17, 页码 6117-6138出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/d1gc01615f
关键词
-
资金
- Austrian Science Fund (FWF) [P 34397-N]
Continuous flow enantioselective catalysis has become a mature field with diverse applications in synthesis of chiral APIs and their intermediates. Various methods such as biocatalysis, organometallic catalysis, and metal-free organocatalysis are utilized in the introduction of asymmetry in continuously operated systems.
Catalytic enantioselective transformations provide well-established and direct access to stereogenic synthons that are broadly distributed among active pharmaceutical ingredients (APIs). These reactions have been demonstrated to benefit considerably from the merits of continuous processing and microreactor technology. Over the past few years, continuous flow enantioselective catalysis has grown into a mature field and has found diverse applications in asymmetric synthesis of pharmaceutically active substances. The present review therefore surveys flow chemistry-based approaches for the synthesis of chiral APIs and their advanced stereogenic intermediates, covering the utilization of biocatalysis, organometallic catalysis and metal-free organocatalysis to introduce asymmetry in continuously operated systems. Single-step processes, interrupted multistep flow syntheses, combined batch/flow processes and uninterrupted one-flow syntheses are discussed herein.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据