期刊
GUT MICROBES
卷 13, 期 1, 页码 -出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/19490976.2021.1949095
关键词
Bile acids; enterohepatic circulation; intestine; FXR
资金
- Science and Technology Program of Guangzhou, China [202103000089]
- Guangdong Demonstration Base for Joint Cultivation of Postgraduates
- Science Foundation for Distinguished Young Scholars of Guangdong [2020B1515020026]
FXR, a nuclear receptor for bile acids, plays a key role in regulating metabolic pathways and improving various diseases. Bile acids link the intestine with the liver through the enterohepatic circulation, with different types of bile acids having diverse effects on the intestines, providing a foundation for new treatment methods.
Farnesoid X receptor (FXR) is a nuclear receptor for bile acids (BAs) that is widely expressed in the intestine, liver and kidney. FXR has important regulatory impacts on a wide variety of metabolic pathways (such as glucose, lipid, and sterol metabolism) and has been recognized to ameliorate obesity, liver damage, cholestasis and chronic inflammatory diseases. The types of BAs are complex and diverse. BAs link the intestine with the liver through the enterohepatic circulation. BAs derivatives have entered clinical trials for liver disease. In addition to the liver, the intestine is also targeted by BAs. This article reviews the effects of different BAs on the intestinal tract through the enterohepatic circulation from the perspective of FXR, aiming to elucidate the effects of different BAs on the intestinal tract and lay a foundation for new treatment methods.
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