期刊
CHEMICAL SCIENCE
卷 12, 期 31, 页码 10410-10425出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/d1sc02236a
关键词
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资金
- Ministerio de Ciencia y Tecnologia e Innovacion Productiva [PICT-2015-3854, PICT-2017-1930]
- Universidad de Buenos Aires (UBACYT) [20020170100595BA]
HNO, a biologically relevant reactive nitrogen species, is highly reactive and impossible to store. Researchers have used donor compounds to study its chemistry, and attempted to stabilize it by coordination to metal centers. Various strategies for its detection have been proposed due to its high reactivity and short lifetime.
HNO (nitroxyl, azanone), joined the 'biologically relevant reactive nitrogen species' family in the 2000s. Azanone is impossible to store due to its high reactivity and inherent low stability. Consequently, its chemistry and effects are studied using donor compounds, which release this molecule in solution and in the gas phase upon stimulation. Researchers have also tried to stabilize this elusive species and its conjugate base by coordination to metal centers using several ligands, like metalloporphyrins and pincer ligands. Given HNO's high reactivity and short lifetime, several different strategies have been proposed for its detection in chemical and biological systems, such as colorimetric methods, EPR, HPLC, mass spectrometry, fluorescent probes, and electrochemical analysis. These approaches are described and critically compared. Finally, in the last ten years, several advances regarding the possibility of endogenous HNO generation were made; some of them are also revised in the present work.
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