期刊
EUROPEAN POLYMER JOURNAL
卷 88, 期 -, 页码 679-688出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.eurpolymj.2016.10.041
关键词
Polyoxazoline; Biomaterial; Polymer-conjugates; Nanomedicine; Tobacco mosaic virus; Stealth coatings
资金
- Deutscher Akademischer Austauschdienst [IPID4all]
- National Science Foundation [CHE 1306447]
- National Institute of Health [R03 EB020602]
- German initiative of excellence through the Dresden Initiative of Bioactive Interfaces & Materials (DIB)
- NIH [T32 GM007250, TL1 TR000441]
- Direct For Mathematical & Physical Scien
- Division Of Chemistry [1306447] Funding Source: National Science Foundation
Polyethylene glycol (PEG) polymers are currently used in a variety of medical formulations to reduce toxicity, minimize immune interactions and improve pharmacokinetics. Despite its widespread use however, the presence of anti-PEG antibodies indicates that this polymer has the potential to be immunogenic and antigenic. Here we present an alternative polymer, poly(2-oxazoline) (PDX) for stealth applications, specifically shielding of a proteinaceous nanoparticle from recognition by the immune system. Tobacco mosaic virus (TMV) was used as our testbed due to its potential for use as a nanocarrier for drug delivery and molecular imaging applications. (C) 2016 Elsevier Ltd. All rights reserved.
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