期刊
EUROPEAN POLYMER JOURNAL
卷 92, 期 -, 页码 294-313出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.eurpolymj.2017.05.015
关键词
Polyurethane; Chitosan; Core-shell; Nanoparticles; Insulin bioavailability
资金
- Department of Science and Technology, Government of India
- project entitled 'Development of Polyurethane vehicle based on Polyethylene Terephthalate (PET) waste for controlled protein drug delivery' [DST/DISHA/SoRF-PM/045/2013]
Waste polyethylene terephthalate (PET) is depolymerized through glycolysis and the glycolyzed product, bis (2-hydroxyethylene) terephthalate (BHET) is utilized in the synthesis of polyurethane as diol. Polyurethane (PU) is incorporated in a core-shell nanoparticle formulation along with alginate (ALG) and chitosan (CS) to develop an efficient oral insulin delivery vehicle. Fourier transform infrared (FT-IR) spectrums of the polyurethane-alginate/chitosan (PU-ALG/CS) nanoparticles confirm the presence of all elements distinctly. Nanoparticles of average particle size 90-110 nm are clearly visible from the images of scanning electron microscope (SEM) and transmission electron microscope (TEM). Unique characteristics of insulin loaded PU-ALG/CS nanoparticles are noticed in both in vitro and in vivo studies. More than 90% insulin encapsulation efficiency, sustained swelling, controlled insulin release from mucoadhesive nanoparticle formulation are the major causes of long term hypoglycaemic effects in diabetic mice and improved insulin bioavailability (10.36%). PU-ALG/CS nanoparticles are also found to be safe, according to the acute toxicity studies.
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