4.4 Article

Myogenetic oligodeoxynucleotide complexed with berberine promotes differentiation of chicken myoblasts

期刊

ANIMAL SCIENCE JOURNAL
卷 92, 期 1, 页码 -

出版社

WILEY
DOI: 10.1111/asj.13597

关键词

berberine; chicken; myoblast; myogenetic oligodeoxynucleotide (myoDN); myogenic differentiation

资金

  1. Nagano Prefecture to Promote Scientific Activity [H29-3-12]
  2. Ito Foundation
  3. Japan Society for the Promotion of Science [18K05939, 19J20888, 19K05948]
  4. Kieikai Research Foundation [2018C002]
  5. Shinshu Foundation for Promotion of Agricultural and Forest Science
  6. Grants-in-Aid for Scientific Research [19J20888, 19K05948, 18K05939] Funding Source: KAKEN

向作者/读者索取更多资源

Research has shown that certain myogenetic oligodeoxynucleotides (myoDNs) can promote the differentiation of chicken myoblasts into MHC-positive myotubes.
Myoblasts are myogenic precursors that develop into myotubes during muscle formation. Improving efficiency of myoblast differentiation is important for advancing meat production by domestic animals. We recently identified novel oligodeoxynucleotides (ODNs) termed myogenetic ODNs (myoDNs) that promote the differentiation of mammalian myoblasts. An isoquinoline alkaloid, berberine, forms a complex with one of the myoDNs, iSN04, and enhances its activities. This study investigated the effects of myoDNs on chicken myoblasts to elucidate their species-specific actions. Seven myoDNs (iSN01-iSN07) were found to facilitate the differentiation of chicken myoblasts into myosin heavy chain (MHC)-positive myotubes. The iSN04-berberine complex exhibited a higher myogenetic activity than iSN04 alone, which was shown to enhance the differentiation of myoblasts into myotubes and the upregulation of myogenic gene expression (MyoD, myogenin, MHC, and myomaker). These data indicate that myoDNs promoting chicken myoblast differentiation may be used as potential feed additives in broiler diets.

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