Synthetic applications of α,α-difluoroarylacetic acids and salts via decarboxylative functionalization

alpha,alpha-Difluoroarylacetic acids are stable, inexpensive and readily available building blocks, which have been recently utilized as synthons to access various difluoromethylated aryl motifs via decarboxylative functionalization, such as alkylation, allylation, alkynylation, arylation, fluorination and the formation of carbon-heteroatom (O, S) bonds. In this review, we systematically summarize the decarboxylative functionalization of alpha,alpha-difluoroarylacetic acids and salts, and their mechanisms are also discussed.

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This review systematically summarizes the decarboxylative functionalization of alpha,alpha-difluoroarylacetic acids and salts, discussing their mechanisms.