期刊
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
卷 17, 期 11, 页码 2737-2755出版社
IVYSPRING INT PUBL
DOI: 10.7150/ijbs.61410
关键词
long non-coding RNA; gastric cancer; drug resistance; helicobacter pylori; tumor microenvironment
资金
- National Natural Science Foundation of China [81803237, 81803812, 81770562]
- Joint Funds of the Southwest Medical University Luzhou, China [2018LZXNYDZK34]
- Science and Technology Planning Project of Luzhou, China [2018-RCM-64]
- National Key R&D Project of China [2018YFC0115301]
This review summarizes the research progress on the roles of long non-coding RNAs (lncRNAs) in gastric cancer (GC), focusing on their involvement in Helicobacter pylori infection, GC metastasis, tumor microenvironment regulation, drug resistance, and associated signaling pathways. LncRNAs may serve as novel biomarkers for diagnosis and prognosis of GC and potential therapeutic targets.
Gastric cancer (GC) is one of the major public health concerns. Long non-coding RNAs (lncRNAs) have been increasingly demonstrated to possess a strong correlation with GC and play a critical role in GC occurrence, progression, metastasis and drug resistance. Many studies have shed light on the understanding of the underlying mechanisms of lncRNAs in GC. In this review, we summarized the updated research about lncRNAs in GC, focusing on their roles in Helicobacter pylori infection, GC metastasis, tumor microenvironment regulation, drug resistance and associated signaling pathways. LncRNAs may serve as novel biomarkers for diagnosis and prognosis of GC and potential therapeutic targets. The research gaps and future directions were also discussed.
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