Platelet-rich fibrin: Basics of biological actions and protocol modifications

Platelet-rich fibrin (PRF) represents second generation of platelet concentrates, which has gained increasing awareness in recent years for regenerative procedures. This biologic additive is completely autologous, easy to prepare, has minimal expense, and possesses prolonged growth factor release, together with several other advantages over traditionally prepared platelet concentrates. Since its introduction, various protocols for PRF preparation have been proposed with different amounts of growth factors and other biomolecules necessary for wound healing. However, reference data about potential effect of some PRF components on hard and soft tissue healing are still conflicting. The current article intends to clarify the relevant advances about physiological role of certain PRF components and to provide insight into the new developmental approach. Also, this review summarizes the evolution of platelet concentrates and biologic properties of different modifications of PRF procedure.

Automated summary

Platelet-rich fibrin (PRF), as a second-generation platelet concentrate, has gained increasing attention in regenerative treatments. Despite conflicting data on the potential effects of PRF components on wound healing, its autologous preparation, low cost, and prolonged growth factor release provide significant advantages. This review aims to clarify the physiological effects of certain PRF components and provide insights into new developmental approaches.