4.7 Article

K2S2O8 activation by glucose at room temperature for the synthesis and functionalization of heterocycles in water

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Article Chemistry, Organic

Possible competitive modes of decarboxylation in the annulation reactions of ortho-substituted anilines and arylglyoxylates

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Summary: This study investigated the annulation reactions of ortho-substituted anilines and arylglyoxylates in the presence of K2S2O8 under metal-free neutral conditions, providing insights into the synthesis and mechanisms of nitrogen heterocycles. The study proposed multiple mechanistic pathways for the formation of heterocycles, highlighting the importance and versatility of using K2S2O8 as a reagent for decarboxylation and transition-metal-free conditions.

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