期刊
GREEN CHEMISTRY
卷 23, 期 17, 页码 6405-6413出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/d1gc02251b
关键词
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资金
- EPSRC [EP/S035990/1]
- GlaxoSmithKline
- EPSRC [EP/S035990/1] Funding Source: UKRI
The Steglich esterification is a commonly used method for ester formation, but issues with hazardous carbodiimide coupling reagents and problematic solvents have been identified. To address these issues, a solvent-reagent selection guide has been developed to provide safer, more sustainable conditions, with optimal conditions identified using high-throughput screening.
The Steglich esterification is a widely employed method for the formation of esters under mild conditions. A number of issues regarding the sustainability of this transformation have been identified, chiefly the use of hazardous carbodiimide coupling reagents in conjunction with solvents with considerable issues such as dichloromethane (DCM) and N,N-dimethylformamide (DMF). To overcome these issues, we have developed a solvent-reagent selection guide for the formation of esters via Steglich-type reactions with the aim of providing safer, more sustainable conditions. Optimum reaction conditions have been identified after high-throughput screening of solvent-reagent combinations, namely the use of Mukaiyama's reagent (Muk) in conjunction with solvent dimethyl carbonate (DMC). The new reaction conditions were also exemplified through the synthesis of a small selection of building-block like molecules and includes the formation of t-butyl esters.
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