2,2′-Bipyrimidine-based luminescent Ru(ii)/Ir(iii)-arene monometallic and homo- and hetero-bimetallic complexes for therapy against MDA-MB-468 and caco-2 cells

To unearth suitable complexes that are capable of inhibiting the growth of MDA-MB-468 and Caco-2 cells, 2,2 '-bipyrimidine-based luminescent Ru(ii)/Ir(iii)-arene monometallic and homo- and hetero-bimetallic complexes were synthesized. The complex [(eta(6)-p-cymene)(eta(5)-Cp*)(RuIrCl2)-Ir-II-Cl-III(K-2-N,N-bipyrimidine)](PF6)(2) [LRuIr] exhibited the best potency in both cells along with good GSH stability and strong binding efficacy with the biomolecules. The apoptotic event occurred in MDA-MB-468 cancer cells via cell cycle arrest.

Automated summary

By synthesizing 2,2'-bipyrimidine-based complexes, LRuIr was found to exhibit inhibitory effects on both MDA-MB-468 and Caco-2 cells, with apoptotic events occurring in MDA-MB-468 cancer cells through cell cycle arrest.