期刊
AGE
卷 37, 期 4, 页码 -出版社
SPRINGER
DOI: 10.1007/s11357-015-9808-7
关键词
Inflammation; Interleukin-6; C-reactive protein; Kidney; Glomerular filtration rate; Race; Aging; Gender; Japanese; African-American
资金
- National Institute on Aging [5R37 AG027343, P01 AG020166]
- General Clinical Research Centers program [M01-RR023942, M01-RR00865]
- Clinical and Translational Science Award (CTSA) program of the National Center for Research Resources [1UL1RR025011]
The objective of this study was to investigate the effects of low-grade inflammation on age-related changes in glomerular filtration rate (GFR) in middle-aged and older white Americans, African-Americans, and Japanese adults. Serum creatinine, C-reactive protein (CRP), and interleukin-6 (IL-6) levels were determined for 1570 adult participants in two surveys of aging in the USA and Japan (N = 1188 and 382, respectively). Kidney function declined with age in both countries and was associated with IL-6 and CRP. IL-6 and CRP also influenced the extent of the arithmetic bias when calculating the GFR using the chronic kidney disease epidemiology (CKD-EPI) formula with just serum creatinine. Younger African-Americans initially had the highest GFR but showed a steep age-related decrement that was associated with elevated inflammation. Japanese adults had the lowest average GFR but evinced a large effect of increased inflammatory activity when over 70 years of age. Importantly, our results also indicate that low-grade inflammation is important to consider when evaluating kidney function solely from serum creatinine.
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