Force-mediated molecule release from double network hydrogels

The incorporation of mechanosensitive linkages into polymers has led to materials with dynamic force responsivity. Here we report oxanorbornadiene cross-linked double network hydrogels that release molecules through a force-mediated retro Diels-Alder reaction. The molecular design and tough double network of polyacrylamide and alginate promote significantly higher activation at substantially less force than pure polymer systems. Activation at physiologically relevant forces provides scope for instilling dynamic mechanochemical behavior in soft biological materials.

Automated summary

Incorporating mechanosensitive linkages into polymers produces materials with dynamic force responsivity. The oxanorbornadiene cross-linked double network hydrogels release molecules through a force-mediated retro Diels-Alder reaction. Activation at physiologically relevant forces enables dynamic mechanochemical behavior in soft biological materials.