期刊
2021 10TH INTERNATIONAL IEEE/EMBS CONFERENCE ON NEURAL ENGINEERING (NER)
卷 -, 期 -, 页码 457-460出版社
IEEE
DOI: 10.1109/NER49283.2021.9441383
关键词
-
资金
- European Union's Horizon 2020 Framework Programme for Research and Innovation [785907]
- HBP Partnering Project (CerebNEST)
The study found that a single active source of NO has a local effect on individual synapses, while multiple closely-located sources act more like a volume transmitter, influencing even inactive synapses within the area. In the cerebellum's input layer, NO produced by granule cells enhances pre-synaptic currents in mossy fiber - granule cell synapses, leading to long-term effects.
Nitric Oxide (NO) is an intracellular messenger whose diffusive properties enable an unconventional type of communication between neurons in the central nervous system that bypasses their anatomical connectivity. In this work, we modeled NO production and diffusion from a single source and investigated the range of action of the NO signal within a bioinspired spiking neural network. We found that a single active source will produce only a local effect on the individual synapse. While if multiple closely-located sources are active at the same time, NO will act more like a volume transmitter and influence even inactive synapses within that area. We focused our attention on the cerebellum's input layer, where NO is produced by the granule cells. In the granular layer, NO acts as a retrograde second messenger able to enhance pre-synaptic currents in the mossy fiber - granule cell synapses, thus potentiating them with long-term effects (LTP).
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