NaI/TBHP-promoted reaction of indole-2-thiones with arylsulfonyl hydrazides: construction of achiral axial 3,3′-biindole-2,2′-dibenzenesulfonothioate derivatives

A new method for the synthesis of achiral axial 3,3 '-biindole-2,2 '-dibenzenesulfonothioate derivatives from indole-2-thiones with arylsulfonyl hydrazides promoted by NaI/TBHP is disclosed. The reaction proceeded smoothly without a transition-metal catalyst under mild conditions, and provides a novel and efficient one-pot strategy to synthesize 3,3 '-biindole-2,2 '-dibenzenesulfonothioate derivatives.

Automated summary

This new method utilizes NaI/TBHP as catalyst to synthesize achiral axial 3,3'-biindole-2,2'-dibenzenesulfonothioate derivatives from arylsulfonyl hydrazides and indole-2-thiones under mild conditions without the need for a transition-metal catalyst.