期刊
JOURNAL OF MATERIALS CHEMISTRY B
卷 9, 期 33, 页码 6623-6633出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/d1tb01097b
关键词
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资金
- National Natural Science Foundation of China [81950410638]
- Key Research and Development Program of Zhejiang Province [2021C01180]
- Zhejiang Natural Science Foundation of China [LQ19E020010]
- Zhejiang International Science and Technology Cooperation Project [2019C04020]
Cancer treatment has been enhanced by nanomaterials with diagnostic and therapeutic effects, with a focus on MRI and phototherapy. Fe-TiO2 nanocomposites exhibit promising properties for cancer theranostics, showing potential for safe in vivo applications.
Cancer treatment has been recently energized by nanomaterials that simultaneously offer diagnostic and therapeutic effects. Among the imaging and treatment modalities in frontline research today, magnetic resonance imaging (MRI) and phototherapy have gained significant interest due to their noninvasiveness among other intriguing benefits. Herein, Fe(iii) was adsorbed on titanium dioxide to develop magnetic Fe-TiO2 nanocomposites (NCs) which leverage the Fe moiety in a double-edge-sword approach to: (i) achieve T-1-weighted MRI contrast enhancement, and (ii) improve the well-established photodynamic therapeutic efficacy of TiO2 nanoparticles. Interestingly, the proposed NCs exhibit classic T-1 MRI contrast agent properties (r(1) = 1.16 mM(-1) s(-1)) that are comparable to those of clinically available contrast agents. Moreover, the NCs induce negligible cytotoxicity in traditional methods and show remarkable support to the proliferation of intestine organoids, an advanced toxicity evaluation system based on three-dimensional organoids, which could benefit their potential safe application for in vivo cancer theranostics. Aided by the Fenton reaction contribution of the Fe component of the Fe-TiO2 NCs, considerable photo-killing of cancer cells is achieved upon UV irradiation at very low (2.5 mW cm(-2)) intensity in typical cancer PDT. It is therefore expected that this study will guide the engineering of other biocompatible magnetic titania-based nanosystems with multi-faceted properties for biomedical applications.
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