期刊
BIOMATERIALS SCIENCE
卷 9, 期 10, 页码 3662-3674出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/d1bm00033k
关键词
-
资金
- National Natural Science Foundation of China [51903015, 81772281]
- Shandong Science and Technology Committee [ZR2019MH022]
- Scientific Research Foundation of Binzhou Medical University [50012304274]
- Shandong Province Taishan Scholar Project [ts201712067]
A multifunctional theranostic platform (MnO2-SiO2-APTES&Ce6 (MSA&C)) incorporating PDT and NIR-II photothermal therapy was developed based on MnO2 nanoflowers. The platform effectively loaded photosensitizer, relieved tumor hypoxia, and provided tumor-specific imaging. The combination of PDT and NIR-II PTT showed improved therapeutic efficacy by enhancing ROS generation and down-regulating HSP 70 expression.
Photodynamic therapy (PDT) has been regarded as a promising strategy for tumor therapy. However, heterogeneous tumor microenvironments severely limit the efficacy of photodynamic therapy. In this work, a multifunctional theranostic platform (MnO2-SiO2-APTES&Ce6 (MSA&C)) was fabricated based on MnO2 nanoflowers, which afforded MRI-guided synergistic therapy incorporating PDT and second near-infrared window (NIR-II) photothermal therapy (PTT). Herein, MnO2 nanoflowers are first proposed as a NIR-II photothermal agent. In the MSA&C system, MnO2 nanoflowers were employed for effective photosensitizer loading, relieving tumor hypoxia, and NIR-II PTT and tumor-specific imaging. The large amount of photosensitizer, reduced tumor hypoxia, and hyperthermia all contributed to the improvement of PDT. The quantity of reactive oxygen species (ROS) generated during PDT in turn down-regulated the expression of heat shock proteins (HSP 70), thereby improving photothermal performance. Positively charged (3-aminopropyl)triethoxysilane (APTES) was used to promote cellular uptake, further improving treatment efficiency. In this system, the MSA&C nanoflowers can not only alleviate tumor hypoxia, but they also obviously induce cell apoptosis under laser irradiation through a ROS- and hyperthermia-mediated mechanism, thereby leading to remarkable tumor growth inhibition. Furthermore, the Mn2+ ions generated during treatment can be explored for MR imaging, and this could be used to finally realize MRI-guided enhanced PDT/PTT.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据