期刊
ERJ OPEN RESEARCH
卷 7, 期 2, 页码 -出版社
EUROPEAN RESPIRATORY SOC JOURNALS LTD
DOI: 10.1183/23120541.00037-2021
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-
资金
- Ministry of Health, Labour and Welfare, Japan [19AA2007, H30-Policy-Designated-004]
- Ministry of Education, Culture, Sports, Science and Technology, Japan [17H04141]
The study found that among patients with AE-IPF, the underweight group had a higher mortality rate, while the obese group had a lower mortality rate.
Background: Idiopathic pulmonary fibrosis (IPF) is an interstitial lung disease characterised by chronic fibrosis, and acute exacerbation of IPF (AE-IPF) is the leading cause of death in patients with IPF. Data on the association between the body mass index (BMI) and prognosis of AE-IPF are lacking. This study was performed to evaluate the association between BMI and in-hospital mortality in patients who developed AE-IPF using a national inpatient database. Methods: Using the Japanese Diagnosis Procedure Combination database, we retrospectively collected data of inpatients with AE-IPF from 1 July, 2010 to 31 March, 2018. We performed a multivariable logistic regression analysis to evaluate the association between all-cause in-hospital mortality and BMI, categorised as underweight (<18.5 kg.m(-2)), low-normal weight (18.5-22.9 kg.m(-2)), high-normal weight (23.0-24.9 kg.m(-2)), overweight (25.0-29.9 kg.m(-2)) and obese (>= 30.0 kg.m(-2)). Results: In total, 14 783 patients were eligible for this study. The in-hospital mortality rate was 59.0%, 55.0%, 53.8%, 54.8% and 46.0% in the underweight, low-normal weight, high-normal weight, overweight and obese groups, respectively. Underweight patients had a significantly higher mortality rate (OR 1.25, 95% CI 1.10-1.42) and obese patients had a significantly lower mortality rate (OR 0.71, 95% CI 0.54-0.94) than low-normal weight patients. Conclusion: Among patients with AE-IPF, the underweight group had higher mortality and the obese group had lower mortality.
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