期刊
JOURNAL OF VETERINARY MEDICAL SCIENCE
卷 83, 期 6, 页码 984-989出版社
JAPAN SOC VET SCI
DOI: 10.1292/jvms.21-0063
关键词
dysbiosis; fecal microbiota transplantation; hypoalbuminemia; non-responsive enteropathy; Shiba dog
A 7-year 6-month-old, castrated male Shiba dog presented with symptoms of lethargy, anorexia, vomiting, and frequent watery diarrhea, diagnosed with non-responsive enteropathy (NRE). Fecal microbiota transplantation (FMT) along with chlorambucil treatment significantly improved the dog's condition.
A 7-year 6-month-old, castrated male Shiba dog presented with a 1-month history of lethargy, anorexia, vomiting, and frequent watery diarrhea. Weight loss, hypoalbuminemia, anemia, and leukocytosis were detected at the first visit. The dog was diagnosed with non-responsive enteropathy (NRE) based on clinical and histopathological examinations. Since the dog did not respond to the immunosuppressive drugs, fecal microbiota transplantation (FMT) was performed during the treatment with chlorambucil. A single endoscopic FMT into the cecum and colon drastically recovered clinical signs and clinicopathological abnormalities and corrected dysbiosis in the dog. No recurrence or adverse events were observed. The present case report suggests that FMT, possibly together with chlorambucil, might be a treatment option for NRE in Shiba dogs that have poorer prognosis compared with other dog breeds.
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