期刊
JOURNAL OF VETERINARY MEDICAL SCIENCE
卷 83, 期 7, 页码 1113-1119出版社
JAPAN SOC VET SCI
DOI: 10.1292/jvms.21-0166
关键词
cattle; Klebsiella pneumoniae; meningoencephalitis; multidrug resistance
The study found that two calves died due to Klebsiella pneumoniae infection leading to bacterial meningoencephalitis, primarily attributed to multidrug-resistant Klebsiella and immunosuppression. This provides new insights into Klebsiella pneumoniae infections in cattle.
One calf died (No. 1) and another was euthanized following astasia (No. 2). Histopathological examination revealed suppurative meningoencephalitis in these calves. Klebsiella pneumoniae antigens were detected in lesions. Thymocytes were decreased in the thymus cortex in both cases. 16S rRNA gene sequencing of the No. 1 isolate and bacterial extracts from formalin fixed paraffin embedded sections of No. 2 revealed that both samples were K. pneumoniae. The No. 1 isolate showed multidrug resistance against penicillin antibiotics, fosfomycin, streptomycin, macrolide antibiotics, tetracycline antibiotics, and clindamycin. Immunosuppression is a significant septicemic K. pneumoniae infection risk factor. Our study provides new aspects regarding K. pneumoniae infections in cattle, bacterial meningoencephalitis differentiation, and K. pneumoniae and bacterial meningoencephalitis treatments.
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