Systematic Review of Serum Biomarkers in Traumatic Brain Injury

Traumatic brain injury (TBI) is responsible for the majority of trauma-related deaths and is a leading cause of disability. It is characterized by an inflammatory process involved in the progression of secondary brain injury. TBI is measured by the Glasgow Coma Scale (GCS) with scores ranging from 15-3, demonstrating mild to severe brain injury. Apart from this clinical assessment of TBI, compendiums of literature have been published on TBI-related serum markers. Herein we create a comprehensive appraisal of the most prominent serum biomarkers used in the assessment and care of TBI. The PubMed, Scopus, Cochrane, and Web of Science databases were queried with the terms biomarker and traumatic brain injury as search terms with only full-text, English articles within the past 10 years selected. Non-human studies were excluded, and only adult patients fell within the purview of this analysis. A total of 528 articles were analyzed in the initial search with 289 selected for screening. A further 152 were excluded for primary screening. Of the remaining 137, 54 were included in the final analysis. Serum biomarkers were listed into the following broad categories for ease of discussion: immune markers and markers of inflammation, hormones as biomarkers, coagulation and vasculature, genetic polymorphisms, antioxidants and oxidative stress, apoptosis and degradation pathways, and protein markers. Glial fibrillary acidic protein (GFAP), S100, and neurons specific enolase (NSE) were the most prominent and frequently cited markers. Amongst these three, no single serum biomarker demonstrated neither superior sensitivity nor specificity compared to the other two, therefore noninvasive panels should incorporate these three serum biomarkers to retain sensitivity and maximize specificity for TBI.

Automated summary

TBI is a major cause of trauma-related deaths and disability, characterized by an inflammatory process in secondary brain injury progression. This study comprehensively evaluates serum biomarkers for TBI, highlighting GFAP, S100, and NSE as prominent markers, suggesting noninvasive panels should include these three for sensitivity and specificity optimization.