相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。Discovery of cryptic allosteric sites using reversed allosteric communication by a combined computational and experimental strategy
Duan Ni et al.
CHEMICAL SCIENCE (2021)
Insight into the mechanism of allosteric activation of PI3Kα by oncoprotein K-Ras4B
Xinyi Li et al.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2020)
RAS-targeted therapies: is the undruggable drugged?
Amanda R. Moore et al.
NATURE REVIEWS DRUG DISCOVERY (2020)
Comparative effects of oncogenic mutations G12C, G12V, G13D, and Q61H on local conformations and dynamics of K-Ras
Sezen Vatansever et al.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL (2020)
The quaternary assembly of KRas4B with Raf-1 at the membrane
Hyunbum Jang et al.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL (2020)
The current understanding of KRAS protein structure and dynamics
Tatu Pantsar
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL (2020)
Small Molecule Allosteric Modulators of G-Protein-Coupled Receptors: Drug-Target Interactions
Shaoyong Lu et al.
JOURNAL OF MEDICINAL CHEMISTRY (2019)
Allosteric Modulator Discovery: From Serendipity to Structure-Based Design
Shaoyong Lu et al.
JOURNAL OF MEDICINAL CHEMISTRY (2019)
Discovery of potent SOS1 inhibitors that block RAS activation via disruption of the RAS-SOS1 interaction
Roman C. Hillig et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)
Drugging K-RasG12C through covalent inhibitors: Mission possible?
Duan Ni et al.
PHARMACOLOGY & THERAPEUTICS (2019)
Deactivation Pathway of Ras GTPase Underlies Conformational Substates as Targets for Drug Design
Shaoyong Lu et al.
ACS CATALYSIS (2019)
Catalytically Competent Nontransforming H-RASG12P Mutant Provides Insight into Molecular Switch Function and GAP-independent GTPase Activity of RAS
Metehan Iiter et al.
SCIENTIFIC REPORTS (2019)
The clinical KRAS(G12C) inhibitor AMG 510 drives anti-tumour immunity
Jude Canon et al.
NATURE (2019)
Pharmacological targeting of RAS: Recent success with direct inhibitors
John P. O'Bryan
PHARMACOLOGICAL RESEARCH (2019)
Tyrosyl phosphorylation of KRAS stalls GTPase cycle via alteration of switch I and II conformation
Yoshihito Kano et al.
NATURE COMMUNICATIONS (2019)
Allosteric Methods and Their Applications: Facilitating the Discovery of Allosteric Drugs and the Investigation of Allosteric Mechanisms
Shaoyong Lu et al.
ACCOUNTS OF CHEMICAL RESEARCH (2019)
Discovery of High-Affinity Noncovalent Allosteric KRAS Inhibitors That Disrupt Effector Binding
Michael J. McCarthy et al.
ACS OMEGA (2019)
The K-Ras, N-Ras, and H-Ras Isoforms: Unique Conformational Preferences and Implications for Targeting Oncogenic Mutants
Jillian A. Parker et al.
COLD SPRING HARBOR PERSPECTIVES IN MEDICINE (2018)
Discovery of hidden allosteric sites as novel targets for allosteric drug design
Shaoyong Lu et al.
DRUG DISCOVERY TODAY (2018)
Therapeutic strategies to target RAS-mutant cancers
Meagan B. Ryan et al.
NATURE REVIEWS CLINICAL ONCOLOGY (2018)
The small GTPases K-Ras, N-Ras, and H-Ras have distinct biochemical properties determined by allosteric effects
Christian W. Johnson et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2017)
Distinct dynamics and interaction patterns in H- and K-Ras oncogenic P-loop mutants
Abdallah Sayyed-Ahmad et al.
PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS (2017)
An engineered protein antagonist of K-Ras/B-Raf interaction
Monique J. Kauke et al.
SCIENTIFIC REPORTS (2017)
Intrinsic protein disorder in oncogenic KRAS signaling
Ruth Nussinov et al.
CELLULAR AND MOLECULAR LIFE SCIENCES (2017)
RAS Proteins and Their Regulators in Human Disease
Dhirendra K. Simanshu et al.
CELL (2017)
Inhibitors of Ras-SOS Interactions
Shaoyong Lu et al.
CHEMMEDCHEM (2016)
Ras Conformational Ensembles, Allostery, and Signaling
Shaoyong Lu et al.
CHEMICAL REVIEWS (2016)
Drugging Ras GTPase: a comprehensive mechanistic and signaling structural view
Shaoyong Lu et al.
CHEMICAL SOCIETY REVIEWS (2016)
RAS mimetic revealed
Alexandra Flemming
NATURE REVIEWS DRUG DISCOVERY (2016)
Direct small-molecule inhibitors of KRAS: from structural insights to mechanism-based design
Jonathan M. L. Ostrem et al.
NATURE REVIEWS DRUG DISCOVERY (2016)
The Structural Basis of Oncogenic Mutations G12, G13 and Q61 in Small GTPase K-Ras4B
Shaoyong Lu et al.
SCIENTIFIC REPORTS (2016)
Direct Attack on RAS: Intramolecular Communication and Mutation-Specific Effects
Kendra Marcus et al.
CLINICAL CANCER RESEARCH (2015)
ff14SB: Improving the Accuracy of Protein Side Chain and Backbone Parameters from ff99SB
James A. Maier et al.
JOURNAL OF CHEMICAL THEORY AND COMPUTATION (2015)
Direct inhibition of oncogenic KRAS by hydrocarbon-stapled SOS1 helices
Elizaveta S. Leshchiner et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)
Allosteric Effects of the Oncogenic RasQ61L Mutant on Raf-RBD
Susan K. Fetics et al.
STRUCTURE (2015)
ZDOCK server: interactive docking prediction of protein-protein complexes and symmetric multimers
Brian G. Pierce et al.
BIOINFORMATICS (2014)
Drugging the undruggable RAS: Mission Possible?
Adrienne D. Cox et al.
NATURE REVIEWS DRUG DISCOVERY (2014)
Src promotes GTPase activity of Ras via tyrosine 32 phosphorylation
Severa Bunda et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)
The RASopathies
Katherine A. Rauen
ANNUAL REVIEW OF GENOMICS AND HUMAN GENETICS, VOL 14 (2013)
K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions
Jonathan M. Ostrem et al.
NATURE (2013)
Electrostatic Effects of Mutations of Ras Glutamine 61 Measured Using Vibrational Spectroscopy of a Thiocyanate Probe
Amy J. Stafford et al.
BIOCHEMISTRY (2012)
NetworkView: 3D display and analysis of protein•RNA interaction networks
John Eargle et al.
BIOINFORMATICS (2012)
A Comprehensive Survey of Ras Mutations in Cancer
Ian A. Prior et al.
CANCER RESEARCH (2012)
The RAS/RAF/MEK/ERK and the PI3K/AKT signalling pathways: role in cancer pathogenesis and implications for therapeutic approaches
Antonella De Luca et al.
EXPERT OPINION ON THERAPEUTIC TARGETS (2012)
Crystal structures of the state 1 conformations of the GTP-bound H-Ras protein and its oncogenic G12V and Q61L mutants
Shin Muraoka et al.
FEBS LETTERS (2012)
The Ras protein superfamily: Evolutionary tree and role of conserved amino acids
Ana Maria Rojas et al.
JOURNAL OF CELL BIOLOGY (2012)
Genetic analysis of Ras signalling pathways in cell proliferation, migration and survival
Matthias Drosten et al.
EMBO JOURNAL (2010)
Structural Basis for Conformational Dynamics of GTP-bound Ras Protein
Fumi Shima et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
Crystal Contacts as Nature's Docking Solutions
Evgeny Krissinel
JOURNAL OF COMPUTATIONAL CHEMISTRY (2010)
Allosteric modulation of Ras positions Q61 for a direct role in catalysis
Greg Buhrman et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
Ras superfamily GEFs and GAPs: validated and tractable targets for cancer therapy?
Dominico Vigil et al.
NATURE REVIEWS CANCER (2010)
Fpocket: An open source platform for ligand pocket detection
Vincent Le Guilloux et al.
BMC BIOINFORMATICS (2009)
Comparison of computational approaches for predicting the effects of missense mutations on p53 function
Lillian T. Chong et al.
JOURNAL OF MOLECULAR GRAPHICS & MODELLING (2009)
Dynamical networks in tRNA: protein complexes
Anurag Sethi et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
Ras oncogenes: split personalities
Antoine E. Karnoub et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2008)
Clustering molecular dynamics trajectories: 1. Characterizing the performance of different clustering algorithms
Jianyin Shao et al.
JOURNAL OF CHEMICAL THEORY AND COMPUTATION (2007)
Inference of macromolecular assemblies from crystalline state
Evgeny Krissinel et al.
JOURNAL OF MOLECULAR BIOLOGY (2007)
Structure of a transient intermediate for GTP hydrolysis by Ras
B Ford et al.
STRUCTURE (2006)
AMBER force-field parameters for phosphorylated amino acids in different protonation states: phosphoserine, phosphothreonine, phosphotyrosine, and phosphohistidine
N Homeyer et al.
JOURNAL OF MOLECULAR MODELING (2006)
Development and testing of a general amber force field
JM Wang et al.
JOURNAL OF COMPUTATIONAL CHEMISTRY (2004)
Insights into protein-protein binding by binding free energy calculation and free energy decomposition for the Ras-Raf and Ras-RaIGDS complexes
H Gohlke et al.
JOURNAL OF MOLECULAR BIOLOGY (2003)
Targeting ras signalling pathways in cancer therapy
J Downward
NATURE REVIEWS CANCER (2003)
Revisiting the structural flexibility of the complex p21ras-GTP:: The catalytic conformation of the molecular switch II
TA Soares et al.
PROTEINS-STRUCTURE FUNCTION AND GENETICS (2001)
The arginine finger of RasGAP helps Gln-61 align the nucleophilic water in GAP-stimulated hydrolysis of GTP
H Resat et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)
Ras proteins in the control of the cell cycle and cell differentiation
P Crespo et al.
CELLULAR AND MOLECULAR LIFE SCIENCES (2000)