期刊
BIOENGINEERED
卷 12, 期 1, 页码 5289-5304出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/21655979.2021.1964252
关键词
Alternative splicing; bladder cancer; prognosis; bone metastasis; signaling pathway
资金
- National Natural Science Foundation of China [81702659, 81772856, 81501203]
- Youth Fund of Shanghai Municipal Health Planning Commission [2017YQ054]
- Shanghai Municipal Health Commission [201940306]
- Henan medical science and technology research project [201602031]
This study constructed a predictive model based on ASEs and explored their molecular mechanism in BLCA bone metastasis, proposing a hypothesis that the splicing events of ITGB4 are regulated by the splicing factor JUP and may play a key role in BLCA bone metastasis through the glycosphingolipid biosynthesis ganglio series pathway.
Bladder cancer (BLCA), originating from the epithelium of the urinary bladder, was the second most common malignancy in the urinary system with a high metastasis rate and poor post-metastasis prognosis. Alternative splicing events (ASEs) were regarded as important markers of tumor progression and prognosis, however, their roles in bladder cancer bone metastasis have not been recognized. In this study, we constructed a predictive model based on ASEs and explored the molecular mechanism of ASEs in BLCA bone metastasis, based on data from the Cancer Genome Atlas (TCGA) and TCGASpliceSeq databases. We proposed the hypothesis that the splicing events of ITGB4 was regulated by the splicing factor JUP, and this regulation might play a key role in BLCA bone metastasis through the glycosphingolipid biosynthesis ganglio series pathway.
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