Crucial Roles of microRNA-Mediated Autophagy in Urologic Malignancies

Urologic oncologies are major public health problems worldwide. Both microRNA and autophagy, separately or concurrently, are involved in a variety of the cellular and molecular processes of multiple cancers, including urologic malignancies. In this review, we have summarized the related studies and found that microRNA-mediated autophagy acted as carcinogenic factors or suppressors in prostate cancer, kidney cancer, and bladder cancer. MiRNAs, targeted genes, and the different signaling pathways constitute a complex network that orchestrates autophagy regulation, militating the oncogenic and tumor-suppressive effects in urologic malignancies. Aberrant expression of miRNAs may induce the dysregulation of the autophagy process, resulting in tumorigenesis, progression, and resistance to anticancer therapies. Targeting specific miRNAs for autophagy modulation may present as reliable diagnostic and prognostic biomarkers or promising therapeutic strategies for urologic oncologies.

Automated summary

MicroRNA-mediated autophagy plays a significant role in urologic malignancies, acting as either carcinogenic factors or suppressors. The complex network involving miRNAs, targeted genes, and signaling pathways regulates autophagy, affecting tumorigenesis, progression, and resistance to anticancer therapies. Targeting specific miRNAs for autophagy modulation may offer reliable diagnostic and prognostic biomarkers or promising therapeutic strategies for urologic oncologies.