Nucleophilic radiosynthesis of boron neutron capture therapy-oriented PET probe [18F]FBPA using aryldiboron precursors

A reliable copper-mediated nucleophilic radiosynthesis of the PET imaging probe [F-18]FBPA was developed using novel aryldiboron precursors. The carrier-free [F-18]FBPA with radiochemical purity >99% was prepared routinely via the two-step synthesis with an automatic module and can be used for clinical PET imaging of tumours.

Automated summary

A reliable copper-mediated nucleophilic radiosynthesis method was developed for preparing the PET imaging probe [F-18]FBPA using novel aryldiboron precursors. The carrier-free [F-18]FBPA with radiochemical purity >99% can be routinely prepared via a two-step synthesis with an automatic module and utilized for clinical PET imaging of tumours.