4.8 Article

Chitinase-3-like 1 protein complexes modulate macrophage-mediated immune suppression in glioblastoma

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A review of glioblastoma immunotherapy

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Summary: Current immunotherapy treatments for glioblastoma, including checkpoint inhibitors and vaccine therapy, have shown disappointing results in clinical trials due to the highly immunosuppressive environment and therapy resistance mechanisms of the tumor. Ongoing research is focusing on exploring combination therapies and novel treatment strategies beyond immune checkpoint therapies, as well as establishing synergy between immunotherapy and current standard of care to improve treatment outcomes. Recent advances in personalized neoantigen vaccines suggest a shift towards personalized, patient-specific treatment for glioblastoma.

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