Association of Adult-Onset Bartter Syndrome With Undifferentiated Connective Tissue Disorder

Bartter syndrome is a rare autosomal recessive, salt-losing disorder characterized by hypokalemic hypochloremic metabolic alkalosis. We are reporting a case of 21 years old patient, who presented with lower limb weakness, marked hypokalemia, proteinuria, and renal impairment detected on laboratory evaluation. The diagnosis of Bartter syndrome was suspected by marked hypokalemia and was supported by renal biopsy which showed evidence of Juxtaglomerular (JG) hyperplasia. This is the first case report about clinicopathological features of the patient with acquired Bartter syndrome and associated undifferentiated connective tissue disorder manifesting as hypokalemia with paralysis.

Automated summary

This case report describes a 21-year-old patient with Bartter syndrome, presenting with hypokalemic hypochloremic metabolic alkalosis, renal impairment, and evidence of JG hyperplasia on renal biopsy. This is the first reported case of acquired Bartter syndrome associated with undifferentiated connective tissue disorder manifesting as hypokalemia with paralysis.