Nickel-catalyzed reductive monofluoroakylation of alkyl tosylate with bromofluoromethane to primary alkyl fluoride

A nickel-catalysed direct terminal monofluoromethlyation between alkyl tosylates and a low-cost, industrial raw material bromofluoromethane has been developed. This transformation has demonstrated high efficiency, mild conditions, and good functional-group compatibility. The key to success of this transformation lies in the ligand and mild base selection, ensuring the generation of various terminal monofluormethylation products.

Automated summary

A nickel-catalysed direct terminal monofluoromethylaion between alkyl tosylates and bromofluoromethane has been developed, demonstrating high efficiency, mild conditions, and good functional-group compatibility. The success of this transformation lies in the selection of ligand and mild base, ensuring the generation of various terminal monofluoromethylation products.