One-pot synthesis of 3-aminofurans using a simple and efficient recyclable CuI/[bmim]PF6 system

A one-pot three-component reaction of several 2-ketoaldehydes, secondary amines and terminal alkynes to access 3-aminofurans proceeded well in [bmim][PF6] using a simple and cheap CuI catalyst. The resultant 3-aminofuran products were easily isolated using diethyl ether and the CuI/[bmim][PF6] system was reused six times with a slight decrease in the activity.

Automated summary

The one-pot three-component reaction using CuI catalyst in [bmim][PF6] to access 3-aminofurans proceeded well, with the resultant products easily isolated and the system reusable up to six times with minimal decrease in activity.