期刊
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
卷 17, 期 12, 页码 3036-3047出版社
IVYSPRING INT PUBL
DOI: 10.7150/ijbs.61566
关键词
Partial EMT; Squamous Cell Carcinoma; FAT1; HIPPO; NOTCH; TGF-beta; Collective migration; Stemness; Therapeutic resistance
资金
- Graduate Research Fund of Guizhou Province [Qian-Jiao-He YJSCXJH [2019] 087]
- Sixth Talent Foundation in Guizhou province [rcjd20199]
- Youth Science and Technology Talents Growth Project of Guizhou Education Department [Qian-Jiao-He KY ZI [2018] 236]
- Outstanding Young Talent Project of Zunyi Medical University [17zy002, F801]
- National Natural Science Foundation of China [82060205]
- The Project to Cultivate Young Scientific and Technological Talents in Colleges and Universities of Guizhou Province [Qian Jiao He KY [2021] 215]
Partial EMT is a plastic state in cancer cells where both epithelial and mesenchymal characteristics are exhibited, regulated by various pathways and molecules, leading to aggressive tumorigenic properties and high stemness, resulting in therapy resistance and metastasis.
In the process of cancer EMT, some subgroups of cancer cells simultaneously exhibit both mesenchymal and epithelial characteristics, a phenomenon termed partial EMT (pEMT). pEMT is a plastic state in which cells coexpress epithelial and mesenchymal markers. In squamous cell carcinoma (SCC), pEMT is regulated, and the phenotype is maintained via the HIPPO pathway, NOTCH pathway and TGF-beta pathways and by microRNAs, lncRNAs and the cancer microenvironment (CME); thus, SCC exhibits aggressive tumorigenic properties and high stemness, which leads collective migration and therapy resistance. Few studies have reported therapeutic interventions to address cells that have undergone pEMT, and this approach may be an effective way to inhibit the plasticity, drug resistance and metastatic potential of SCC.
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