期刊
EUROPEAN JOURNAL OF PHARMACOLOGY
卷 796, 期 -, 页码 7-19出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ejphar.2016.12.004
关键词
Arachidonic acid cascade; G protein-coupled receptor; Inflammatory bowel diseases; Colorectal cancer; Gastrointestinal physiology
资金
- Spanish Ministry of Education and Sciences [BFI2001-3397, BFU2004-04960, BFU2007-61727, AGL2013-49083-C3-1-R]
- Generalitat de Catalunya [2005SGR00269, 2009SGR00438]
The importance of cyclooxygenase and lipoxygenase pathways and the consequent eicosanoid synthesis in the physiology and pathophysiology of the intestinal epithelium is currently being established. Each eicosanoid (prostanoid, leukotriene, hydroxyeicosatetraenoic acid) preferentially recognizes one or more receptors coupled to one or more signal-transduction processes. This overview focuses on the role of eicosanoid receptors in the maintenance of intestinal epithelium physiology through the control of proliferation/differentiation/apoptosis processes. Furthermore, it is reported that the role of these receptors on the regulation of the barrier function of the intestinal epithelium have arisen through the regulation of absorption/secretion processes, tight-junction state and the control of the intestinal immune response. Also, this review considers the implication of AA cascade in the disruption of epithelial homeostasis during inflammatory bowel diseases and colorectal cancer as well as the therapeutic values and potential of the eicosanoid receptors as novel targets for the treatments of the pathologies above mentioned.
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