期刊
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
卷 117, 期 -, 页码 39-48出版社
ELSEVIER
DOI: 10.1016/j.ejpb.2017.03.018
关键词
Organoselenium; Selenium; Nanotechnology; Stability studies; Nanotoxicology; Biodistribution
资金
- UFSM
- FAPERGS [2239-2551/14]
- CNPq [(441405/2014-2]
- CNPq
Organoselenium compounds have been targeted to new therapeutic tools development due to their pharmacological actions. However, some toxicity issues and physicochemical limitations delay the clinical application of these compounds. The incorporation of organoselenium molecules into nanostructured systems arises as a promising alternative to overcome such restrictions. The current study proposed the characterization of the polymeric nanocapsules of p,p'-methoxyl-diphenyl diselenide [(OMePhSe)(2)] as well as the evaluation of the in vivo toxicity and biodistribution profile. The nanocapsules, which were composed by medium-chain triglycerides as the oil core and poly(epsilon-caprolactone) as the polymeric wall, showed nanometric size (236 +/- 4), low polydispersity (<0.2), negative zeta potential (-5.4 +/- 0.06), neutral pH values (7.2 +/- 0.08) and a high encapsulation efficiency (98%). Besides, the nanoencapsulation process increased the (OMePhSe)2 stability. The repeated intragastric administration of (OMePhSe)(2) nanoencapsulated (25 mg/kg/day during 7 days) did not cause any alteration in the oxidative status, hematological parameters, and plasma biochemical markers of cellular damage. Moreover, the (OMePhSe)(2) incorporation into nanocapsules increased the selenium concentrations in the tissues (kidneys, liver and plasma) suggesting an improvement in its oral bioavailability. (C) 2017 Elsevier B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据