SARS-CoV-2, COVID-19 and the aging immune system

The coronavirus disease 2019 (COVID-19) pandemic is a global health threat with particular risk for severe disease and death in older adults and in adults with age-related metabolic and cardiovascular disease. Recent advances in the science of aging have highlighted how aging pathways control not only lifespan but also healthspan - the healthy years of life. Here, we discuss the aging immune system and its ability to respond to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). We specifically focus on the intersect of severe COVID-19 and immunosenescence to highlight pathways that may be determinant for the risk of complications and death following infection with SARS-CoV-2. New or adapted therapeutics that target aging-associated pathways may be important tools to reduce the burden of death and long-term disability caused by this pandemic. Proposed interventions aimed at immunosenescence could enhance immune function not only in older adults but in susceptible younger individuals as well, ultimately improving complications of severe COVID-19 for all ages.

Automated summary

The COVID-19 pandemic poses a greater risk for severe disease and death in older adults and individuals with age-related metabolic and cardiovascular diseases. Interventions targeting immunosenescence may be crucial in reducing mortality and disability caused by the pandemic, ultimately improving complications associated with severe COVID-19 in individuals of all ages.