期刊
JOURNAL OF PRIMARY CARE AND COMMUNITY HEALTH
卷 12, 期 -, 页码 -出版社
SAGE PUBLICATIONS INC
DOI: 10.1177/21501327211028714
关键词
statin; necrotizing; myopathy; adverse; effects; neurology; hyperlipidemia
Statin-induced autoimmune myopathy is a rare but serious complication that requires careful attention to patients' medical history and medication use for timely diagnosis and treatment.
Statin therapy is a widely prescribed medication class for hypercholesterolemia. In statin-induced autoimmune myopathy, genetically predisposed and at-risk patients can develop antibodies against hydroxy-3-methylglutaryl-CoA reductase (HMGCR), the key enzyme in the production of cholesterol. As a result, an autoimmune reaction causing weakness, myalgia, with possible severe rhabdomyolysis, renal failure, and myonecrosis also can occur. A 73-year-old female presented to clinic with myalgia and fatigue. She was on atorvastatin 20 mg/day for over 1 year, which she stopped 1 week prior to her initial presentation. Patient did experience rhabdomyolysis as well as a transaminitis. She underwent an autoimmune workup which was positive for HMG-CoA reductase antibodies. Patient was initially treated on a prednisone taper, starting dose 50 mg/day. Without remission of symptoms, methotrexate 15 mg/week was initiated.
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