Practical resources for enhancing the reproducibility of mechanistic modeling in systems biology

Although reproducibility is a core tenet of the scientific method, it remains challenging to reproduce many results. Tiwari et al. recently found that they could only repeat 50% of published simulation results in systems biology. We identified several resources that investigators can leverage to make their research more accessible, executable, and comprehensible by others., Enhanced reproducibility would accelerate the development of more sophisticated models that could inform precision medicine and synthetic biology.

Automated summary

Although reproducibility is crucial in the scientific method, it is challenging to replicate many results. Researchers have found that only 50% of published simulation results in systems biology can be repeated. By utilizing various resources, investigators can make their research more accessible, executable, and comprehensible to others. Improved reproducibility will accelerate the development of more sophisticated models, benefiting precision medicine and synthetic biology.