☆ 4.4 Review

A scoping review of the pathophysiology of COVID-19

INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY (2021)

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Article Cardiac & Cardiovascular Systems

Severe coronary spasm in aCOVID-19 patient

Fernando Rivero et al.

Summary: Coronary artery spasm can lead to acute coronary syndrome in COVID-19 patients, even when coronary angiography shows normal arteries. This pathophysiological mechanism was clearly demonstrated using intravascular imaging techniques and invasive vasospasm testing.

CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS (2021)

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Review Virology

Epidemiology of COVID-19: A systematic review and meta-analysis of clinical characteristics, risk factors, and outcomes

Jie Li et al.

Summary: COVID-19 presents with a variety of clinical features and outcomes, with an average age of 46.7 years, 51.8% of patients being male, 22.9% having severe disease, and a mortality rate of 5.6%. Severity of the disease is associated with factors such as age, gender, and comorbidities, which also increase the risk of mortality.

JOURNAL OF MEDICAL VIROLOGY (2021)

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Article Pathology

Severe COVID-19: A multifaceted viral vasculopathy syndrome

Cynthia M. Magro et al.

Summary: This study reveals two distinct mechanisms of severe COVID-19 infection: microangiopathy of pulmonary capillaries with high viral load leading to endothelial cell death, and pseudovirions docking on ACE2+ endothelial cells in skin/subcutaneous fat and brain triggering complement pathway/coagulation cascade and cytokine storm. The data suggests potential therapies targeting circulating viral proteins or endothelial-induced response for a favorable outcome.

ANNALS OF DIAGNOSTIC PATHOLOGY (2021)

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Letter Pathology

Comments to: A systematic review of pathological findings in COVID-19: a pathophysiological timeline and possible mechanisms of disease progression

Rafael Parra-Medina et al.

MODERN PATHOLOGY (2021)

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Article Medicine, Research & Experimental

COVID-19 and Immunological Dysregulation: Can Autoantibodies be Useful?

Simona Pascolini et al.

Summary: Auto-antibodies are frequently detected in patients with COVID-19, potentially indicating a role in immune dysregulation and a link to poor prognosis.

CTS-CLINICAL AND TRANSLATIONAL SCIENCE (2021)

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Article Infectious Diseases

MATH plus protocol for the treatment of SARS-CoV-2 infection: the scientific rationale

Paul E. Marik et al.

Summary: The pulmonary phase of COVID-19 is characterized by organizing pneumonia with immune dysregulation, clotting activation, and microvascular injury leading to severe hypoxemia. The MATH+ protocol combines methylprednisolone, ascorbic acid, thiamine, and heparin to manage this phase. While there is no single cure for COVID-19, the MATH+ protocol is believed to effectively treat respiratory failure and prevent complications and death.

EXPERT REVIEW OF ANTI-INFECTIVE THERAPY (2021)

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Letter Immunology

Coronavirus disease associated immune thrombocytopenia: Causation or correlation?

Simona Pascolini et al.

JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION (2021)

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Article Critical Care Medicine

Critically Ill COVID-19 Patients With Acute Kidney Injury Have Reduced Renal Blood Flow and Perfusion Despite Preserved Cardiac Function: A Case-Control Study Using Contrast-Enhanced Ultrasound

James Watchorn et al.

Summary: The study compared renal perfusion and blood flow in COVID-19 patients with acute kidney injury, septic shock patients, and healthy volunteers. Results showed reduced perfusion parameters and blood flow in COVID-19 patients, suggesting a potential renal-vascular pathogenesis of COVID-19 associated AKI.

SHOCK (2021)

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Article Critical Care Medicine

Occurrence of Invasive Pulmonary Fungal Infections in Patients with Severe COVID-19 Admitted to the ICU

Arnaud Fekkar et al.

Summary: This study examined the occurrence of invasive fungal respiratory superinfections in severe COVID-19 patients admitted to five ICUs in France, finding that patients with no underlying immunosuppression seem at low risk of invasive fungal secondary infection.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2021)

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Article Critical Care Medicine

Tissue-Specific Immunopathology in Fatal COVID-19

David A. Dorward et al.

Summary: In fatal COVID-19 cases, abnormal immune responses were found primarily in the lung and reticuloendothelial system, which were not clearly associated with the virus. Tissue-specific immunopathology in COVID-19 implicates a significant role of immune-mediated, virus-independent mechanisms in severe disease.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2021)

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Review Chemistry, Medicinal

Overview of COVID-19 inflammatory pathogenesis from the therapeutic perspective

Choongho Lee et al.

Summary: The novel coronavirus SARS-CoV-2, known as COVID-19, has had a devastating impact on the global economy and healthcare systems, changing the definition of normal life. Developing effective therapeutics and preventive measures is crucial in fighting SARS-CoV-2 infection and restoring normalcy. Understanding COVID-19 pathogenesis is essential in guiding the development of anti-COVID-19 drugs and vaccines.

ARCHIVES OF PHARMACAL RESEARCH (2021)

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Article Immunology

High frequency of cerebrospinal fluid autoantibodies in COVID-19 patients with neurological symptoms

Christiana Franke et al.

Summary: The study on critically ill COVID-19 patients presenting with unexplained neurological symptoms found that all patients showed anti-neuronal autoantibodies in serum or CSF, which may be related to clinical symptoms, particularly hyperexcitability. Several underlying autoantigens and their potential molecular mimicry with SARS-CoV-2 still need further identification.

BRAIN BEHAVIOR AND IMMUNITY (2021)

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Article Cell Biology

Discriminating mild from critical COVID-19 by innate and adaptive immune single-cell profiling of bronchoalveolar lavages

Els Wauters et al.

Summary: Single-cell deep-immune profiling revealed that specific T cells in mild COVID-19 patients exhibit active expansion and function, while in critical COVID-19 they remain more naive. Furthermore, the monocyte-to-macrophage trajectories show enrichment of chronic hyperinflammatory monocytes and depletion of anti-inflammatory alveolar macrophages in critical COVID-19.

CELL RESEARCH (2021)

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Article Immunology

Inflammasomes are activated in response to SARS-CoV-2 infection and are associated with COVID-19 severity in patients

Tamara S. Rodrigues et al.

Summary: The active NLRP3 inflammasome in response to SARS-CoV-2 infection is associated with disease severity in COVID-19 patients, with higher levels of IL-18 and Casp1p20 correlating with poor clinical outcomes. These findings suggest that inflammasomes may serve as markers of disease severity and potential therapeutic targets for COVID-19.

JOURNAL OF EXPERIMENTAL MEDICINE (2021)

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Article Virology

Peripheral Blood Immune Profiling of Convalescent Plasma Donors Reveals Alterations in Specific Immune Subpopulations Even at 2 Months Post SARS-CoV-2 Infection

Nikolaos Orologas-Stavrou et al.

Summary: Immune profiling of COVID-19 patients shows severe lymphocyte deficiencies and increased levels of pro-inflammatory monocytes. Analysis of peripheral blood samples revealed that recovered donors had restored immune profiles for most subpopulations, but still showed reduced levels of certain immune cells even 2 months after recovery. Previously hospitalized donors showed distinct alterations in their immune profiles.

VIRUSES-BASEL (2021)

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Review Microbiology

The role of Neuropilin-1 in COVID-19

Bindu S. Mayi et al.

Summary: NRP-1, a member of a family of signaling proteins, plays a critical role in SARS-CoV-2 infection and may be involved in immune function, transmission pathways, and disease severity. Research suggests NRP-1 could serve as a therapeutic target in SARS-CoV-2 infections, highlighting the need for further study.

PLOS PATHOGENS (2021)

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Review Critical Care Medicine

Clinical and Scientific Rationale for the MATH plus Hospital Treatment Protocol for COVID-19

Pierre Kory et al.

Summary: Following the emergence of the COVID-19 pandemic, the Front-Line COVID-19 Critical Care Alliance was formed to develop a treatment protocol, named MATH+, based on core therapies and co-interventions to reduce mortality rates in patients with acute respiratory failure. This protocol was established through collaborative efforts among front-line clinical ICU experts from China, Italy, and New York, and was supported by published scientific and clinical data on the efficacy of the therapies used in the treatment of viral syndromes and COVID-19. The review of this protocol also compared the outcomes of patients treated with MATH+ to multi-national mortality data, demonstrating its potential effectiveness in improving patient outcomes.

JOURNAL OF INTENSIVE CARE MEDICINE (2021)

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Article Medicine, General & Internal

SARS-CoV-2 Transmission From People Without COVID-19 Symptoms

Michael A. Johansson et al.

Summary: The study suggests that more than half of COVID-19 transmission may come from asymptomatic individuals, highlighting the importance of measures beyond identifying and isolating symptomatic cases in controlling the spread of the virus.

JAMA NETWORK OPEN (2021)

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Article Allergy

Potential association of mast cells with coronavirus disease 2019

Theoharis C. Theoharides

ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY (2021)

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Article Hematology

Vascular Endothelial Damage in the Pathogenesis of Organ Injury in Severe COVID-19

Annabelle Dupont et al.

Summary: The study investigated the association between endothelial damage and immune dysregulation with organ failure, thrombus formation, and death in 82 patients with COVID-19, finding a direct role of endotheliopathy in organ failure and an association between dysregulated immune response and respiratory failure, liver injury, and death. Thrombi from COVID-19 patients on extracorporeal membrane oxygenation showed increased neutrophil accumulation and neutrophil extracellular traps compared to non-COVID-19 thrombi.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2021)

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Article Biochemistry & Molecular Biology

Association between antidepressant use and reduced risk of intubation or death in hospitalized patients with COVID-19: results from an observational study

Nicolas Hoertel et al.

Summary: This study suggests that the use of antidepressants in patients hospitalized for COVID-19 may be associated with a lower risk of death or intubation. Antidepressants such as fluoxetine, paroxetine, escitalopram, venlafaxine, and mirtazapine showed significant associations with reduced risk. Further research in the form of double-blind controlled randomized clinical trials is recommended.

MOLECULAR PSYCHIATRY (2021)

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Article Multidisciplinary Sciences

Furin cleavage of the SARS-CoV-2 spike is modulated by O-glycosylation

Liping Zhang et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2021)

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Article Immunology

Mast Cell and Eosinophil Activation Are Associated With COVID-19 and TLR-Mediated Viral Inflammation: Implications for an Anti-Siglec-8 Antibody

Simon Gebremeskel et al.

Summary: The activation of MC and eosinophils are associated with inflammation in COVID-19, and anti-Siglec-8 antibodies could be a potential therapeutic approach for reducing excessive inflammation during viral infections.

FRONTIERS IN IMMUNOLOGY (2021)

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Article Immunology

Prospective Cohort of Fluvoxamine for Early Treatment of Coronavirus Disease 19

David Seftel et al.

Summary: In this study, 65 individuals opted to receive fluvoxamine for COVID-19 treatment, with a 0% hospitalization rate and 0% residual symptoms. In comparison, 48 individuals who chose observation alone had a hospitalization rate of 12.5% and residual symptoms in 60% of cases. This suggests that fluvoxamine may help alleviate the severity and duration of COVID-19.

OPEN FORUM INFECTIOUS DISEASES (2021)

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Article Microbiology

Recovery of Innate Immune Cells and Persisting Alterations in Adaptive Immunity in the Peripheral Blood of Convalescent Plasma Donors at Eight Months Post SARS-CoV-2 Infection

Ioannis Kostopoulos et al.

Summary: This study analyzed the immune cell profiles of 47 convalescent plasma donors at eight months post COVID-19 infection, revealing significant changes in immune subset composition. While components of innate immunity showed full recovery, T cell polarization remained stable at eight months, with persisting low levels of total B cells detected after infection.

MICROORGANISMS (2021)

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Letter Hematology

Platelet reactivity to thrombin differs between patients with COVID-19 and those with ARDS unrelated to COVID-19

Younes Zaid et al.

BLOOD ADVANCES (2021)

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Article Pharmacology & Pharmacy

Review of the Emerging Evidence Demonstrating the Efficacy of Ivermectin in the Prophylaxis and Treatment of COVID-19

Pierre Kory et al.

Summary: In the context of the COVID-19 pandemic, ivermectin has emerged as a promising treatment option with significant improvements in clinical outcomes and reduced risks of contracting the virus being reported in numerous trials. Additionally, evidence suggests that ivermectin distribution campaigns have led to population-wide decreases in morbidity and mortality, indicating its effectiveness across all phases of the disease.

AMERICAN JOURNAL OF THERAPEUTICS (2021)

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Article Pathology

Endothelial cell damage is the central part of COVID-19 and a mouse model induced by injection of the S1 subunit of the spike protein *

Gerard J. Nuovo et al.

Summary: Neurologic complications of symptomatic COVID-19 are commonly seen, with brain tissues from autopsies showing the presence of pseudovirions in endothelial cells. The spike protein was found to induce ACE2+ endothelial damage, highlighting its central role in SARS-CoV2 pathology. Immunohistochemistry for caspase-3 and ACE2 can be used by diagnostic pathologists to document endothelial cell damage in COVID-19.

ANNALS OF DIAGNOSTIC PATHOLOGY (2021)

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Editorial Material Medicine, Research & Experimental

Antinuclear antibodies in COVID 19

Paolo Muratori et al.

CTS-CLINICAL AND TRANSLATIONAL SCIENCE (2021)

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Letter Critical Care Medicine

COVID-19-associated autoimmunity as a feature of acute respiratory failure

Uriel Trahtemberg et al.

INTENSIVE CARE MEDICINE (2021)

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Article Medicine, General & Internal

US Case Reports of Cerebral Venous Sinus Thrombosis With Thrombocytopenia After Ad26.COV2.S Vaccination, March 2 to April 21, 2021

Isaac See et al.

Summary: Cases of CVST with thrombocytopenia following Ad26.COV2.S vaccination have been reported in the US, leading to serious outcomes. This case series may provide guidance for clinical management and further investigation into the potential relationship between Ad26.COV2.S vaccine and CVST with thrombocytopenia.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2021)

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Article Oncology

SARS-CoV-2 interacts with platelets and megakaryocytes via ACE2-independent mechanism

Shu Shen et al.

Summary: Evidence suggests that SARS-CoV-2 interacts with platelets and megakaryocytes via an ACE2-independent mechanism, potentially regulating expression of alternative receptors associated with COVID-19 coagulation dysfunction.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2021)

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Article Multidisciplinary Sciences

Diverse functional autoantibodies in patients with COVID-19

Eric Y. Wang et al.

Summary: COVID-19 patients show increased autoantibody reactivities against immunomodulatory proteins, which may affect immune function and lead to different clinical outcomes.

NATURE (2021)

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Article Multidisciplinary Sciences

A molecular single-cell lung atlas of lethal COVID-19

Johannes C. Melms et al.

Summary: Single-nucleus RNA sequencing of lung tissues from individuals who died of COVID-19 revealed a highly inflamed lung environment with impaired T cell responses and failed transition of alveolar type 2 cells. Additionally, expansion of pathological fibroblasts contributing to rapidly ensuing pulmonary fibrosis in COVID-19 was identified as a unique feature compared to other causes of pneumonia.

NATURE (2021)

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Review Biochemistry & Molecular Biology

Post-acute COVID-19 syndrome

Ani Nalbandian et al.

Summary: SARS-CoV-2 is responsible for the COVID-19 pandemic, causing global healthcare crises. Recovery from COVID-19 may lead to persistent symptoms and long-term complications, prompting the need for multidisciplinary care and follow-up for survivors.

NATURE MEDICINE (2021)

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Review Multidisciplinary Sciences

Prevalence and outcomes of co-infection and superinfection with SARS-CoV-2 and other pathogens: A systematic review and meta-analysis

Jackson S. Musuuza et al.

Summary: Our study found that as many as 19% of patients with COVID-19 had co-infections and 24% had superinfections. The presence of either co-infection or superinfection was associated with poor outcomes, such as increased mortality.

PLOS ONE (2021)

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Article Pathology

Diffuse interstitial pneumonia-like/macrophage activation syndrome-like changes in patients with COVID-19 correlate with length of illness

Juan C. Felix et al.

Summary: This study evaluated the pathological changes in the lungs of 12 COVID-19 decedents and identified two distinct patterns of pulmonary involvement, which were correlated with a significant difference in the duration of illness. Cases with acute alveolar damage had a duration of illness of 5.7 days, while cases with increased intra-alveolar macrophages had a duration of illness of 21.5 days.

ANNALS OF DIAGNOSTIC PATHOLOGY (2021)

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Letter Medicine, General & Internal

SARS-CoV-2 Delta VOC in Scotland: demographics, risk of hospital admission, and vaccine effectiveness

Aziz Sheikh et al.

LANCET (2021)

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Editorial Material Medicine, General & Internal

Characteristics of and Important Lessons From the Coronavirus Disease 2019 (COVID-19) Outbreak in China Summary of a Report of 72 314 Cases From the Chinese Center for Disease Control and Prevention

Zunyou Wu et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2020)

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Article Oncology

Pulmonary Pathology of Early-Phase 2019 Novel Coronavirus (COVID-19) Pneumonia in Two Patients With Lung Cancer

Sufang Tian et al.

JOURNAL OF THORACIC ONCOLOGY (2020)

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Article Biology

Clinical and biochemical indexes from 2019-nCoV infected patients linked to viral loads and lung injury

Yingxia Liu et al.

SCIENCE CHINA-LIFE SCIENCES (2020)

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Review Hematology

Hematological findings and complications of COVID-19

Evangelos Terpos et al.

AMERICAN JOURNAL OF HEMATOLOGY (2020)

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Article Biochemistry & Molecular Biology

SARS-CoV-2 Reverse Genetics Reveals a Variable Infection Gradient in the Respiratory Tract

Yixuan J. Hou et al.

CELL (2020)

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Article Biochemistry & Molecular Biology

Imbalanced Host Response to SARS-CoV-2 Drives Development of COVID-19

Daniel Blanco-Melo et al.

CELL (2020)

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Article Microbiology

Complex Immune Dysregulation in COVID-19 Patients with Severe Respiratory Failure

Evangelos J. Giamarellos-Bourboulis et al.

CELL HOST & MICROBE (2020)

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Editorial Material Immunology

Functional exhaustion of antiviral lymphocytes in COVID-19 patients

Meijuan Zheng et al.

CELLULAR & MOLECULAR IMMUNOLOGY (2020)

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Article Cell Biology

Pulmonary pathology of early-phase COVID-19 pneumonia in a patient with a benign lung lesion

Zhi Zeng et al.

HISTOPATHOLOGY (2020)

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Editorial Material Critical Care Medicine

COVID-19 pneumonia: different respiratory treatments for different phenotypes?

Luciano Gattinoni et al.

INTENSIVE CARE MEDICINE (2020)

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Review Biochemistry & Molecular Biology

Viroporins and inflammasomes: A key to understand virus-induced inflammation

N. S. Farag et al.

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2020)

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Article Medical Laboratory Technology

Complement associated microvascular injury and thrombosis in the pathogenesis of severe COVID-19 infection: A report of five cases

Cynthia Magro et al.

TRANSLATIONAL RESEARCH (2020)

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Article Infectious Diseases

Expression of the SARS-CoV-2 cell receptor gene ACE2 in a wide variety of human tissues

Meng-Yuan Li et al.

INFECTIOUS DISEASES OF POVERTY (2020)

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Review Immunology

Fighting the Host Reaction to SARS-COv-2 in Critically Ill Patients: The Possible Contribution of Off-Label Drugs

Stefania Scala et al.

FRONTIERS IN IMMUNOLOGY (2020)

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Article Multidisciplinary Sciences

Structure of the SARS-CoV-2 spike receptor-binding domain bound to the ACE2 receptor

Jun Lan et al.

NATURE (2020)

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Article Multidisciplinary Sciences

Virological assessment of hospitalized patients with COVID-2019

Roman Woelfel et al.

NATURE (2020)

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Article Biochemistry & Molecular Biology

Single-cell landscape of bronchoalveolar immune cells in patients with COVID-19

Mingfeng Liao et al.

NATURE MEDICINE (2020)

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Article Medicine, General & Internal

Pulmonary Vascular Endothelialitis, Thrombosis, and Angiogenesis in Covid-19

Maximilian Ackermann et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

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Letter Medicine, General & Internal

ST-Segment Elevation in Patients with Covid-19-A Case Series

Sripal Bangalore et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

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Letter Medicine, General & Internal

Neurologic Features in Severe SARS-CoV-2 Infection

Julie Helms et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

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Article Medicine, General & Internal

Renin-Angiotensin-Aldosterone System Inhibitors in Patients with Covid-19

Muthiah Vaduganathan et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

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Article Radiology, Nuclear Medicine & Medical Imaging

Assessment of Small Pulmonary Blood Vessels in COVID-19 Patients Using HRCT

Muriel Lins et al.

ACADEMIC RADIOLOGY (2020)

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Article Endocrinology & Metabolism

Type 1 diabetes onset triggered by COVID-19

Lucien Marchand et al.

ACTA DIABETOLOGICA (2020)

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Article Critical Care Medicine

Why COVID-19 Silent Hypoxemia Is Baffling to Physicians

Martin J. Tobin et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2020)

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Letter Cardiac & Cardiovascular Systems

Platelet and Vascular Biomarkers Associate With Thrombosis and Death in Coronavirus Disease

Tessa J. Barrett et al.

CIRCULATION RESEARCH (2020)

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Review Medicine, Research & Experimental

Organ-specific manifestations of COVID-19 infection

Maria Gavriatopoulou et al.

CLINICAL AND EXPERIMENTAL MEDICINE (2020)

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Article Hematology

Neutrophil extracellular traps contribute to immunothrombosis in COVID-19 acute respiratory distress syndrome

Elizabeth A. Middleton et al.

BLOOD (2020)

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Letter Hematology

Haemophagocytosis in bone marrow aspirates in patients with COVID-19

Agathe Debliquis et al.

BRITISH JOURNAL OF HAEMATOLOGY (2020)

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Article Immunology

The Lung Macrophage in SARS-CoV-2 Infection: A Friend or a Foe?

Zaid Abassi et al.

FRONTIERS IN IMMUNOLOGY (2020)

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Article Immunology

The Potential Effect of Novel Coronavirus SARS-CoV-2 on NK Cells; A Perspective on Potential Therapeutic Interventions

Anahid Jewett

FRONTIERS IN IMMUNOLOGY (2020)

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Article Medicine, General & Internal

Alveolar macrophage dysfunction and cytokine storm in the pathogenesis of two severe COVID-19 patients

Chaofu Wang et al.

EBIOMEDICINE (2020)

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Article Medicine, Research & Experimental

Impaired immune cell cytotoxicity in severe COVID-19 is IL-6 dependent

Alessio Mazzoni et al.

JOURNAL OF CLINICAL INVESTIGATION (2020)

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Article Immunology

Immunoserologic Detection and Diagnostic Relevance of Cross-Reactive Autoantibodies in Coronavirus Disease 2019 Patients

Maria Teresa Schiaffino et al.

JOURNAL OF INFECTIOUS DISEASES (2020)

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Article Infectious Diseases

Pulmonary post-mortem findings in a series of COVID-19 cases from northern Italy: a two-centre descriptive study

Luca Carsana et al.

LANCET INFECTIOUS DISEASES (2020)

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Article Hematology

Platelet activation and platelet-monocyte aggregate formation trigger tissue factor expression in patients with severe COVID-19

Eugenio D. Hottz et al.

BLOOD (2020)

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Review Biochemistry & Molecular Biology

An aberrant STAT pathway is central to COVID-19

Toshifumi Matsuyama et al.

CELL DEATH AND DIFFERENTIATION (2020)

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Correction Cell Biology

Elevated Glucose Levels Favor SARS-CoV-2 Infection and Monocyte Response through a HIF-1α/Glycolysis-Dependent Axis (vol 32, pg 437, 2020)

Ana Campos Codo et al.

CELL METABOLISM (2020)

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Article Biotechnology & Applied Microbiology

COVID-19 severity correlates with airway epithelium-immune cell interactions identified by single-cell analysis

Robert Lorenz Chua et al.

NATURE BIOTECHNOLOGY (2020)

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Article Cardiac & Cardiovascular Systems

Platelets Can Associate With SARS-CoV-2 RNA and Are Hyperactivated in COVID-19

Younes Zaid et al.

CIRCULATION RESEARCH (2020)

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Article Multidisciplinary Sciences

Impaired type I interferon activity and inflammatory responses in severe COVID-19 patients

Jerome Hadjadj et al.

SCIENCE (2020)

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Article Pathology

Docked severe acute respiratory syndrome coronavirus 2 proteins within the cutaneous and subcutaneous microvasculature and their role in the pathogenesis of severe coronavirus disease 2019

Cynthia M. Magro et al.

HUMAN PATHOLOGY (2020)

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Review Microbiology

Interplay between SARS-CoV-2 and the type I interferon response

Margarida Sa Ribero et al.

PLOS PATHOGENS (2020)

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Review Medical Laboratory Technology

Ferritin in the coronavirus disease 2019 (COVID-19): A systematic review and meta-analysis

Linlin Cheng et al.

JOURNAL OF CLINICAL LABORATORY ANALYSIS (2020)

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Article Immunology

SARS-CoV-2-triggered neutrophil extracellular traps mediate COVID-19 pathology

Flavio Protasio Veras et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2020)

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Article Oncology

SARS-CoV-2 binds platelet ACE2 to enhance thrombosis in COVID-19

Si Zhang et al.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2020)

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Review Medicine, General & Internal

SARS-CoV-2 immunity: review and applications to phase 3 vaccine candidates

Gregory A. Poland et al.

LANCET (2020)

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Article Pathology

COVID-19 pulmonary pathology: a multi-institutional autopsy cohort from Italy and New York City

Alain C. Borczuk et al.

MODERN PATHOLOGY (2020)

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Article Multidisciplinary Sciences

Autoantibodies against type I IFNs in patients with life-threatening COVID-19

Paul Bastard et al.

SCIENCE (2020)

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Article Hematology

Derivation and Validation of a Predictive Score for Disease Worsening in Patients with COVID-19

Grigoris T. Gerotziafas et al.

THROMBOSIS AND HAEMOSTASIS (2020)

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Article Multidisciplinary Sciences

Two distinct immunopathological profiles in autopsy lungs of COVID-19

Ronny Nienhold et al.

NATURE COMMUNICATIONS (2020)

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Article Cell Biology

Evasion of Type I Interferon by SARS-CoV-2

Hongjie Xia et al.

CELL REPORTS (2020)

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Article Critical Care Medicine

Pathophysiology of COVID-19-associated acute respiratory distress syndrome: a multicentre prospective observational study

Giacomo Grasselli et al.

LANCET RESPIRATORY MEDICINE (2020)

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Article Immunology

Mast Cells in Alveolar Septa of COVID-19 Patients: A Pathogenic Pathway That May Link Interstitial Edema to Immunothrombosis

Jarbas da Silva Motta Junior et al.

FRONTIERS IN IMMUNOLOGY (2020)

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Article Cell Biology

SARS-CoV-2 Spike 1 Protein Controls Natural Killer Cell Activation via the HLA-E/NKG2A Pathway

Daria Bortolotti et al.

CELLS (2020)

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Article Biochemistry & Molecular Biology

Quick COVID-19 Healers Sustain Anti-SARS-CoV-2 Antibody Production

Yuezhou Chen et al.

CELL (2020)

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Article Medicine, General & Internal

Fluvoxamine vs Placebo and Clinical Deterioration in Outpatients With Symptomatic COVID-19 A Randomized Clinical Trial

Eric J. Lenze et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2020)

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Article Medicine, General & Internal

Risk Factors Associated With In-Hospital Mortality in a US National Sample of Patients With COVID-19

Ning Rosenthal et al.

JAMA NETWORK OPEN (2020)

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Article Medicine, General & Internal

Evidence of Long-Distance Droplet Transmission of SARS-CoV-2 by Direct Air Flow in a Restaurant in Korea

Keun-Sang Kwon et al.

JOURNAL OF KOREAN MEDICAL SCIENCE (2020)

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Article Cell Biology

Prothrombotic autoantibodies in serum from patients hospitalized with COVID-19

Yu Zuo et al.

SCIENCE TRANSLATIONAL MEDICINE (2020)

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Article Multidisciplinary Sciences

The emerging role of neutrophil extracellular traps in severe acute respiratory syndrome coronavirus 2 (COVID-19)

Angelica Arcanjo et al.

SCIENTIFIC REPORTS (2020)

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Article Infectious Diseases

Viral presence and immunopathology in patients with lethal COVID-19: a prospective autopsy cohort study

Bernadette Schurink et al.

LANCET MICROBE (2020)

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Article Infectious Diseases

Covid-19 hyperinflammation and post-Covid-19 illness may be rooted in mast cell activation syndrome

Lawrence B. Afrin et al.

INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES (2020)

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Letter Critical Care Medicine

Co-infections in COVID-19 critically ill and antibiotic management: a prospective cohort analysis

Alexia Verroken et al.

CRITICAL CARE (2020)

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Article Respiratory System

SARS-CoV-2 organising pneumonia: 'Has there been a widespread failure to identify and treat this prevalent condition in COVID-19?'

Pierre Kory et al.

BMJ OPEN RESPIRATORY RESEARCH (2020)

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Article Immunology

Transcriptomic characteristics of bronchoalveolar lavage fluid and peripheral blood mononuclear cells in COVID-19 patients

Yong Xiong et al.

EMERGING MICROBES & INFECTIONS (2020)

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Article Physiology

Attenuation of pulmonary ACE2 activity impairs inactivation of des-Arg(9) bradykinin/BKB1R axis and facilitates LPS-induced neutrophil infiltration

Chhinder P. Sodhi et al.

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2018)

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Article Multidisciplinary Sciences

Platelets release pathogenic serotonin and return to circulation after immune complex-mediated sequestration

Nathalie Cloutier et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)

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Article Microbiology

Complement Activation Contributes to Severe Acute Respiratory Syndrome Coronavirus Pathogenesis

Lisa E. Gralinski et al.

MBIO (2018)

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Article Physiology

Comparative Expression of Renin-Angiotensin Pathway Proteins in Visceral Versus Subcutaneous Fat

Yuebo Zhang et al.

FRONTIERS IN PHYSIOLOGY (2018)

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Article Immunology

Sex-Based Differences in Susceptibility to Severe Acute Respiratory Syndrome Coronavirus Infection

Rudragouda Channappanavar et al.

JOURNAL OF IMMUNOLOGY (2017)

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Review Medicine, General & Internal

Acute respiratory distress syndrome

Rob Mac Sweeney et al.

LANCET (2016)

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Article Rheumatology

Brief Report: Anti-Eukaryotic Initiation Factor 2B Autoantibodies Are Associated With Interstitial Lung Disease in Patients With Systemic Sclerosis

Zoe E. Betteridge et al.

ARTHRITIS & RHEUMATOLOGY (2016)

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Article Physiology

Time Domains of the Hypoxic Ventilatory Response and Their Molecular Basis

Matthew E. Pamenter et al.

COMPREHENSIVE PHYSIOLOGY (2016)

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Review Medicine, General & Internal

Mast Cells, Mastocytosis, and Related Disorders

Theoharis C. Theoharides et al.

NEW ENGLAND JOURNAL OF MEDICINE (2015)

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Article Critical Care Medicine

Quantitative Diagnosis of Diffuse Alveolar Damage Using Extravascular Lung Water

Takashi Tagami et al.

CRITICAL CARE MEDICINE (2013)

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Article Immunology

Innate Immunity and Its Regulation by Mast Cells

Ashley L. St John et al.

JOURNAL OF IMMUNOLOGY (2013)

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Article Immunology

Extraordinary GU-rich single-strand RNA identified from SARS coronavirus contributes an excessive innate immune response

Yan Li et al.

MICROBES AND INFECTION (2013)

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Article Nutrition & Dietetics

Vitamin C: A Novel Regulator of Neutrophil Extracellular Trap Formation

Bassem M. Mohammed et al.

NUTRIENTS (2013)

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Article Hematology

Platelets can enhance vascular permeability

Nathalie Cloutier et al.

BLOOD (2012)

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Article Medicine, Research & Experimental

Effect of Antiserotonin Drug on the Development of Lung Fibrosis and Blood System Reactions after Intratracheal Administration of Bleomycin

E. G. Skurikhin et al.

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE (2012)

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Article Clinical Neurology

Decreased serotonin content and reduced agonist-induced aggregation in platelets of patients chronically medicated with SSRI drugs

Yona Bismuth-Evenzal et al.

JOURNAL OF AFFECTIVE DISORDERS (2012)

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Review Medicine, Research & Experimental

The acute respiratory distress syndrome

Michael A. Matthay et al.

JOURNAL OF CLINICAL INVESTIGATION (2012)

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Article Virology

Evidence that TMPRSS2 Activates the Severe Acute Respiratory Syndrome Coronavirus Spike Protein for Membrane Fusion and Reduces Viral Control by the Humoral Immune Response

Ilona Glowacka et al.

JOURNAL OF VIROLOGY (2011)

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Review Immunology

Recognition of viruses by cytoplasmic sensors

Courtney Wilkins et al.

CURRENT OPINION IN IMMUNOLOGY (2010)

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Article Virology

A Single Asparagine-Linked Glycosylation Site of the Severe Acute Respiratory Syndrome Coronavirus Spike Glycoprotein Facilitates Inhibition by Mannose-Binding Lectin through Multiple Mechanisms

Yanchen Zhou et al.

JOURNAL OF VIROLOGY (2010)

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Article Microbiology

SARS-CoV Pathogenesis Is Regulated by a STAT1 Dependent but a Type I, II and III Interferon Receptor Independent Mechanism

Matthew B. Frieman et al.

PLOS PATHOGENS (2010)

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Article Critical Care Medicine

Validation of extravascular lung water measurement by single transpulmonary thermodilution: human autopsy study

Takashi Tagami et al.

CRITICAL CARE (2010)

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Article Biochemistry & Molecular Biology

Angiotensin-(1-7) enhances angiotensin II induced phosphorylation of ERK1/2 In mouse bone marrow-derived dendritic cells

Wencheng Nie et al.

MOLECULAR IMMUNOLOGY (2009)

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Article Multidisciplinary Sciences

Simultaneous Activation of Complement and Coagulation by MBL-Associated Serine Protease 2

Anders Krarup et al.

PLOS ONE (2007)

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Article Biochemistry & Molecular Biology

A crucial role of angiotensin converting enzyme 2 (ACE2) in SARS coronavirus-induced lung injury

K Kuba et al.

NATURE MEDICINE (2005)

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Article Multidisciplinary Sciences

Angiotensin-converting enzyme 2 protects from severe acute lung failure

Y Imai et al.

NATURE (2005)

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Article Critical Care Medicine

The concept of baby lung

L Gattinoni et al.

INTENSIVE CARE MEDICINE (2005)

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Article Hematology

The influence of selective serotonin reuptake inhibitors on human platelet serotonin

E Maurer-Spurej et al.

THROMBOSIS AND HAEMOSTASIS (2004)

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Article Critical Care Medicine

Deterioration of previous acute lung injury during neutropenia recovery

E Azoulay et al.

CRITICAL CARE MEDICINE (2002)

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Article Medicine, General & Internal

Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome.

RG Brower et al.

NEW ENGLAND JOURNAL OF MEDICINE (2000)

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Review Medicine, General & Internal

Medical progress - The acute respiratory distress syndrome.

LB Ware et al.

NEW ENGLAND JOURNAL OF MEDICINE (2000)

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Article Clinical Neurology

Reduction of platelet serotonin content in depressed patients treated with either paroxetine or desipramine

MA Javors et al.

INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY (2000)

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Review Pharmacology & Pharmacy

5-hydroxytryptamine and the pulmonary circulation: receptors, transporters and relevance to pulmonary arterial hypertension

MR MacLean et al.

BRITISH JOURNAL OF PHARMACOLOGY (2000)

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