The Use of the Antigenic Protein HPV6 L1 to Induce the Synthesis of Interferon, CD4 and CD8 T Lymphocytes, and Granzyme B in Blood and Splenocytes of Mice in Order to Develop a Broad Vaccine against Anogenital Papillomatoses

The antigenic protein HPV6 L1 was synthesized in the plant expression system based on transgenic tomato fruit during the development of an oral vaccine against anogenital papillomaviruses. In experiments on mice immunization, new data on the induction of the T-cell immune response were obtained, which were recorded by the results of activation of the synthesis of interferon, CD4 and CD8 T lymphocytes, and granzyme B secreted by them in peripheral mononuclear blood cells and splenocytes of mice that were previously vaccinated with the vaccine material of tomato fruit with the HPV6 L1 gene.

Automated summary

The antigenic protein HPV6 L1 was synthesized in a plant expression system using transgenic tomato fruit for the development of an oral vaccine against anogenital papillomaviruses. New data on the induction of T-cell immune response in mice immunization experiments showed activation of interferon, CD4 and CD8 T lymphocytes, and granzyme B secretion in peripheral blood cells and splenocytes of vaccinated mice.