期刊
JOURNAL OF GENETICS AND GENOMICS
卷 48, 期 9, 页码 803-814出版社
SCIENCE PRESS
DOI: 10.1016/j.jgg.2021.05.004
关键词
SARS-CoV-2/COVID-19; Upper respiratory microbiome; Gut microbiota; Dysbiosis; Children
资金
- National Key Research and Development Program of China [2018YFC2000500, 2017ZX10103009002]
- Major Science and Technology Project in Yunnan Province of China [202001BB050001]
- Second Tibetan Plateau Scientific Expedition and Research (STEP) program [2019QZKK0503]
- Key Research Program of the Chinese Academy of Sciences [FZDSW219]
- Chinese National Natural Science Foundation of China [31970571]
- Children 's Hospital of Fudan University [EKXGZX006]
Children infected with SARS-CoV-2 may experience significant alterations in their upper respiratory and gut microbiomes, characterized by dysbiosis and sustained changes lasting for a considerable period. This could indicate potential long-term complications post-recovery from COVID-19.
Children are less susceptible to coronavirus disease 2019 (COVID-19), and they have manifested lower morbidity and mortality after infection, for which a multitude of mechanisms may be considered. Whether the normal development of the gut-airway microbiome in children is affected by COVID-19 has not been evaluated. Here, we demonstrate that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection alters the upper respiratory tract and the gut microbiomes in nine children. The alteration of the microbiome is dominated by the genus Pseudomonas, and it sustains for up to 25-58 days in different individuals. Moreover, the patterns of alternation are different between the upper respiratory tract and the gut. Longitudinal investigation shows that the upper respiratory tract and the gut microbiomes are extremely variable among children during the course of COVID-19. The dysbiosis of microbiome persists in 7 of 8 children for at least 19-24 days after discharge from the hospital. Disturbed development of both the gut and the upper respiratory microbiomes and prolonged dysbiosis in these nine children imply possible long-term complications after clinical recovery from COVID-19, such as predisposition to the increased health risk in the post-COVID-19 era. Copyright (C) 2021, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, and Genetics Society of China. Published by Elsevier Limited and Science Press. All rights reserved.
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