期刊
FOOD & FUNCTION
卷 12, 期 20, 页码 9793-9807出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/d1fo01468d
关键词
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资金
- National Natural Science Foundation of China [31871752, 31901647, 32072175]
- Key Research and Development Plan in Shaanxi Province [2020ZDLSF01-07, 2021NY-184]
- Fundamental Research Funds for the Central Universities of Shaanxi Normal University [GK201803074, GK202103100, TD2020043Y, GK2020-1601021041]
- Development Program for Innovative Research Team of Shaanxi Normal University [GK202101006]
- Sci-Tech Innovation Team of Shaanxi Province, China [2019TD-035]
- China Postdoctoral Science Foundation [2019M650255]
The study demonstrated that turmeric polysaccharides (TPS) can significantly improve the pathological phenotype and colon inflammation in colitis mice by modulating gut microbiota, improving microbial metabolites, and enhancing gut barrier function.
Gut barrier dysfunction is triggered by gut microbiota dysbiosis that is closely associated with ulcerative colitis. Recently, more attention has been devoted to the ability of the non-digestively colon-targeted plant polysaccharides to regulate the function and composition of the intestinal microbiota. Here, we first studied the prophylactic capacity of turmeric polysaccharides (TPS) to ameliorate dextran sulfate sodium (DSS)-induced gut microbiota imbalance. The results revealed that TPS administration could greatly improve the pathological phenotype, gut barrier disruption and colon inflammation in colitis mice. Besides, targeted metabolomics or 16S rRNA-based microbiota analysis demonstrated that TPS alleviated gut microbiota dysbiosis caused by DSS, especially increasing the abundance of probiotics associated with tryptophan metabolism, such as Lactobacillus and Clostridia-UCG-014, where the cecal tryptophan catabolite indole-3-acetic acid (IAA) and its ligand aryl hydrocarbon receptor (AhR) expressions were sharply increased by TPS treatment in colitis mice. Expectedly, TPS was found to exert its gut barrier functions through the activation of AhR to upregulate epithelial tight junction proteins. These findings highlight the protective effects of TPS against ulcerative colitis by modulating the gut microbiota and improving microbial metabolites and gut barrier function.
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