期刊
EUROPEAN JOURNAL OF PEDIATRICS
卷 176, 期 2, 页码 241-252出版社
SPRINGER
DOI: 10.1007/s00431-016-2831-6
关键词
Metabolic risk factors; Insulin resistance; Youth; Metabolic criteria
类别
资金
- European Community Sixth RTD Framework Programme [FOOD-CT-2005-007034]
- Research Foundation Flanders (FWO)
- Spanish Ministry of Economy and Competitiveness [BES-2014-068829]
- Spanish Ministry of Science and Innovation [RYC-2011-09011]
Various definitions are used to define metabolic syndrome in adolescents. This study aimed to compare, in terms of prevalence and differences, five frequently used definitions for this population: International Diabetes Federation, National Cholesterol Education Program Adult Treatment Panel III (NCEP-ATP) modified by Cook, pediatric American Heart Association (AHA), World Health Organization, and Jolliffe and Janssen. A sample of 1004 adolescents (12.5-17.0 years) from the Healthy Lifestyle in Europe by Nutrition in Adolescence (HELENA) study was considered. The components of the definitions (waist circumference/BMI, plasma lipids, glycemia, and blood pressure) were applied, and definitions were compared by using crosstabs, sensitivity, specificity, and kappa coefficient. The prevalence of metabolic syndrome varied from 1.6 to 3.8% depending on the used definitions. Crosstabs comparing the definitions showed the fewest cases being misclassified (having metabolic syndrome or not) between NCEP-ATP and AHA. Analyses for kappa coefficient, sensitivity, and specificity confirmed this finding. Conclusion: The different definitions do not classify the same adolescents as having MS and prevalence varied between diagnostic methods. The modified NCEP-ATP and the AHA definitions were most analogous in defining subjects as having metabolic syndrome or not.
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