Controlling Coagulation in Blood with Red Light

Precise control of blood clotting and rapid reversal of anticoagulation are essential in many clinical situations. We were successful in modifying a thrombin-binding aptamer with a red-light photocleavable linker derived from Cy7 by Cu-catalyzed Click chemistry. We were able to show that we can successfully deactivate the modified aptamer with red light (660 nm) even in human blood-restoring the blood's natural coagulation capability.

Automated summary

The research team successfully controlled blood clotting and reversed anticoagulation by modifying a thrombin-binding aptamer with a red-light photocleavable linker derived from Cy7 using Cu-catalyzed Click chemistry. They demonstrated that the modified aptamer could be deactivated with red light (660 nm) in human blood, restoring the blood's natural coagulation capability.